ReviewNature materials2015
Smart hybrid materials by conjugation of responsive polymers to biomacromolecules.
Review in Nature materials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
108 citing papers in PubMed, 569 citations in OpenAlex.
- A Self-Adaptive Programming Strategy Enables Local Microenvironment Modulation and Temporal Immunomodulation for Diabetic Infected Bone Regeneration.Advanced healthcare materials · 2026Article
- Enhanced volumetric additive manufacturing via Reversible Addition-Fragmentation Chain Transfer (RAFT) polymerization.Nature communications · 2026Article
- Versatile and Selective Biomolecule Pulldown with Combinatorial DNA-Crosslinked Polymers.Angewandte Chemie (International ed. in English) · 2026Article
- Spatiotemporally controlled delivery of biomacromolecules via injectable hydrogels for precision modulation of the tumor immune microenvironment.Journal of nanobiotechnology · 2025Review
- pH Controlled Activation and Stabilization of Enzymes Using Responsive Polymer-Bioconjugates.Biomacromolecules · 2025Article
- Thermo-Responsive Polymer-Based Nanoparticles: From Chemical Design to Advanced Applications.Macromolecular rapid communications · 2025Review
- Hydrogels from Protein-Polymer Conjugates: A Pathway to Next-Generation Biomaterials.Gels (Basel, Switzerland) · 2025Review
- Artificial Zymogen Based on Protein-Polymer Hybrids.Biomacromolecules · 2024Article
- Sequence-encoded bioactive protein-multiblock polymer conjugates via quantitative one-pot iterative living polymerization.Nature communications · 2024Article
- The enhanced photocatalytic performance of CPAA doping with different concentrations of Titanium oxide nanocomposite against MB dyes under simulated sunlight irradiations.Scientific reports · 2024Article
- Article
- Supramolecular Assembly and Thermogelation Strategies Using Peptide-Polymer Conjugates.Biomacromolecules · 2024Review
- An organometallic swap strategy for bottlebrush polymer-protein conjugate synthesis.Chemical communications (Cambridge, England) · 2024Article
- Site-selected in situ polymerization for living cell surface engineering.Nature communications · 2023Article
- Two-Photon Polymerization: Fundamentals, Materials, and Chemical Modification Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Microneedle-Mediated Transdermal Delivery of Biopharmaceuticals.Pharmaceutics · 2023Review
- Preparation of Temperature-Responsive Antibody-Nanoparticles by RAFT-Mediated Grafting from Polymerization.Polymers · 2022Article
- Polynorbornene-based bioconjugates by aqueous grafting-from ring-opening metathesis polymerization reduce protein immunogenicity.Cell reports. Physical science · 2022Article
- Trinuclear Magnesium Imidazolate Borohydride Complex.Inorganic chemistry · 2022Article
- Iron oxide nanoparticles as a drug carrier reduce host immunosuppression for enhanced chemotherapy.Nanoscale · 2022Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The chemical structure and function of biomacromolecules has evolved to fill many essential roles in biological systems. More specifically, proteins, peptides, nucleic acids and polysaccharides serve as vital structural components, and mediate chemical transformations and energy/information storage processes required to sustain life. In many cases, the properties and applications of biological macromolecules can be further expanded by attaching synthetic macromolecules. The modification of biomacromolecules by attaching a polymer that changes its properties in response to environmental variations, thus affecting the properties of the biomacromolecule, has led to the emergence of a new family of polymeric biomaterials. Here, we summarize techniques for conjugating responsive polymers to biomacromolecules and highlight applications of these bioconjugates reported so far. In doing so, we aim to show how advances in synthetic tools could lead to rapid expansion in the variety and uses of responsive bioconjugates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.