ArticleProteins2015
Frequent side chain methyl carbon-oxygen hydrogen bonding in proteins revealed by computational and stereochemical analysis of neutron structures.
Article in Proteins, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
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- A Highly Ordered Nitroxide Side Chain for Distance Mapping and Monitoring Slow Structural Fluctuations in Proteins.Applied magnetic resonance · 2024Article
- Engineering Azobenzene Derivatives to Control the Photoisomerization Process.The journal of physical chemistry. A · 2023Article
- Pharmaceutical Salts of Piroxicam and Meloxicam with Organic Counterions.Crystal growth & design · 2022Article
- Backbone and side-chain resonance assignments of the NISTmAb-scFv and antigen-binding study.Biomolecular NMR assignments · 2022Article
- Dissecting the Kinetic Mechanism of Human Lysine Methyltransferase 2D and Its Interactions with the WRAD2 Complex.Biochemistry · 2022Article
- Phosphoserine inhibits neighboring arginine methylation in the RKS motif of histone H3.Archives of biochemistry and biophysics · 2021Article
- When are two hydrogen bonds better than one? Accurate first-principles models explain the balance of hydrogen bond donors and acceptors found in proteins.Chemical science · 2021Article
- Design of new quinolin-2-one-pyrimidine hybrids as sphingosine kinases inhibitors.Bioorganic chemistry · 2020Article
- Exploring the Role of Consecutive Addition of Nitrogen Atoms on Stability and Reactivity of Hydrogen-Bonded Azine-Water Complexes.ACS omega · 2019Article
- PRMT7 as a unique member of the protein arginine methyltransferase family: A review.Archives of biochemistry and biophysics · 2019Review
- Structural insights into methylated DNA recognition by the C-terminal zinc fingers of the DNA reader protein ZBTB38.The Journal of biological chemistry · 2018Article
- The ribosome: A hot spot for the identification of new types of protein methyltransferases.The Journal of biological chemistry · 2018Article
- A Polyamide Inhibits Replication of Vesicular Stomatitis Virus by Targeting RNA in the Nucleocapsid.Journal of virology · 2018Article
- CH···O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso.Biochemistry · 2018Article
- Engineering protein stability with atomic precision in a monomeric miniprotein.Nature chemical biology · 2017Article
- On the satisfaction of backbone-carbonyl lone pairs of electrons in protein structures.Protein science : a publication of the Protein Society · 2016Article
- Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA.Nucleic acids research · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The propensity of backbone Cα atoms to engage in carbon-oxygen (CH · · · O) hydrogen bonding is well-appreciated in protein structure, but side chain CH · · · O hydrogen bonding remains largely uncharacterized. The extent to which side chain methyl groups in proteins participate in CH · · · O hydrogen bonding is examined through a survey of neutron crystal structures, quantum chemistry calculations, and molecular dynamics simulations. Using these approaches, methyl groups were observed to form stabilizing CH · · · O hydrogen bonds within protein structure that are maintained through protein dynamics and participate in correlated motion. Collectively, these findings illustrate that side chain methyl CH · · · O hydrogen bonding contributes to the energetics of protein structure and folding.
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