ArticlePloS one2014
Reduction of the cytosolic phosphoglucomutase in Arabidopsis reveals impact on plant growth, seed and root development, and carbohydrate partitioning.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 71 citations in OpenAlex.
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- The plastidial α-glucan phosphorylase modulates maltodextrin metabolism and affects starch parameters in Arabidopsis thaliana.Journal of experimental botany · 2025Article
- Engineering the Novel Extremophile AlgaACS ES&T engineering · 2025Article
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- Gaining or cutting SLAC: the evolution of plant guard cell signalling pathways.The New phytologist · 2024Article
- Metabolome and Transcriptome Association Analysis Reveals Mechanism of Synthesis of Nutrient Composition in Quinoa (Foods (Basel, Switzerland) · 2024Article
- Cryptic divergences and repeated hybridizations within the endangered "living fossil" dove tree (Plant diversity · 2024Article
- Structure and Expression Analysis ofInternational journal of molecular sciences · 2023Article
- Metabolic regulation of quiescence in plants.The Plant journal : for cell and molecular biology · 2023Article
- Cytosolic phosphoglucose isomerase is essential for microsporogenesis and embryogenesis in Arabidopsis.Plant physiology · 2023Article
- Unique and Shared Proteome Responses of Rice Plants (International journal of molecular sciences · 2022Article
- Plastidial Phosphoglucomutase (Genes · 2022Article
- Proteomics data analysis using multiple statistical approaches identified proteins and metabolic networks associated with sucrose accumulation in sugarcane.BMC genomics · 2022Article
- Integrated mRNA and Small RNA Sequencing Reveals a microRNA Regulatory Network Associated with Starch Biosynthesis in Lotus (International journal of molecular sciences · 2022Article
- Identification, Characteristics and Function of Phosphoglucomutase (PGM) in the Agar Biosynthesis and Carbon Flux in the AgarophyteMarine drugs · 2022Article
- Sucrose synthases are not involved in starch synthesis in Arabidopsis leaves.Nature plants · 2022Article
- Unravelling theMolecules (Basel, Switzerland) · 2022Article
- A type-2C protein phosphatase (GhDRP1) participates in cotton (Gossypium hirsutum) response to drought stress.Plant molecular biology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphoglucomutase (PGM) catalyses the interconversion of glucose 1-phosphate (G1P) and glucose 6-phosphate (G6P) and exists as plastidial (pPGM) and cytosolic (cPGM) isoforms. The plastidial isoform is essential for transitory starch synthesis in chloroplasts of leaves, whereas the cytosolic counterpart is essential for glucose phosphate partitioning and, therefore, for syntheses of sucrose and cell wall components. In Arabidopsis two cytosolic isoforms (PGM2 and PGM3) exist. Both PGM2 and PGM3 are redundant in function as single mutants reveal only small or no alterations compared to wild type with respect to plant primary metabolism. So far, there are no reports of Arabidopsis plants lacking the entire cPGM or total PGM activity, respectively. Therefore, amiRNA transgenic plants were generated and used for analyses of various parameters such as growth, development, and starch metabolism. The lack of the entire cPGM activity resulted in a strongly reduced growth revealed by decreased rosette fresh weight, shorter roots, and reduced seed production compared to wild type. By contrast content of starch, sucrose, maltose and cell wall components were significantly increased. The lack of both cPGM and pPGM activities in Arabidopsis resulted in dwarf growth, prematurely die off, and inability to develop a functional inflorescence. The combined results are discussed in comparison to potato, the only described mutant with lack of total PGM activity.
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