ArticleThe Journal of clinical investigation2014
The plastic liver: differentiated cells, stem cells, every cell?
Article in The Journal of clinical investigation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Knockout of LATS1 induces neoplastic phenotype in hepatic oval cells.Translational cancer research · 2020Article
- Myofibroblast induces hepatocyte-to-ductal metaplasia via laminin-ɑvβ6 integrin in liver fibrosis.Cell death & disease · 2020Article
- Toward a Reconceptualization of Stem Cells from Cellular Plasticity.International journal of stem cells · 2019Article
- Next-Generation Liver Medicine Using Organoid Models.Frontiers in cell and developmental biology · 2019Review
- YAP Activation Drives Liver Regeneration after Cholestatic Damage Induced byInternational journal of molecular sciences · 2018Article
- The balancing act of the liver: tissue regeneration versus fibrosis.The Journal of clinical investigation · 2018Review
- Periodic acid‑Schiff staining method for function detection of liver cells is affected by 2% horse serum in induction medium.Molecular medicine reports · 2017Article
- Road to stemness in hepatocellular carcinoma.World journal of gastroenterology · 2017Review
- Immunological aspects of liver cell transplantation.World journal of transplantation · 2016Review
- Activin A-Smad Signaling Mediates Connective Tissue Growth Factor Synthesis in Liver Progenitor Cells.International journal of molecular sciences · 2016Article
- Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure.Scientific reports · 2016Article
- The Role of Butylidenephthalide in Targeting the Microenvironment Which Contributes to Liver Fibrosis Amelioration.Frontiers in pharmacology · 2016Article
Corrections and comments
- Comment on
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The liver is capable of full regeneration following several types and rounds of injury, ranging from hepatectomy to toxin-mediated damage. The source of this regenerative capacity has long been a hotly debated topic. The damage response that occurs when hepatocyte proliferation is impaired is thought to be mediated by oval/dedifferentiated progenitor cells, which replenish the hepatocyte and ductal compartments of the liver. Recently, reports have questioned whether these oval/progenitor cells truly serve as the facultative stem cell of the liver following toxin-mediated damage. In this issue of the JCI, Kordes and colleagues use lineage tracing to follow transplanted rat hepatic stellate cells, a resident liver mesenchymal cell population, in hosts that have suffered liver damage. Transplanted stellate cells repopulated the damaged rat liver by contributing to the oval cell response. These data establish yet another cell type of mesenchymal origin as the progenitor for the oval/ductular response in the rat. The lack of uniformity between different damage models, the extent of the injury to the liver parenchyma, and potential species-specific differences might be at the core of the discrepancy between different studies. Taken together, these data imply a considerable degree of plasticity in the liver, whereby several cell types can contribute to regeneration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.