ReviewFrontiers in cellular and infection microbiology2014
Friends with social benefits: host-microbe interactions as a driver of brain evolution and development?
Review in Frontiers in cellular and infection microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 134 citations in OpenAlex.
- The Neuroimmunology of Autism.Molecular neurobiology · 2025Review
- The Larval and Adult Female Gut Microbiomes of Two Burying Beetles (Nicrophorus spp.) With Distinct Parental Care Traits.Environmental microbiology · 2025Article
- Microbiome: A Key Regulator of Body-Brain Interactions.Advances in experimental medicine and biology · 2025Review
- The Impact of Early-Life Cecal Microbiota Transplantation on Social Stress and Injurious Behaviors in Egg-Laying Chickens.Microorganisms · 2024Review
- Overview of Direct and Indirect Effects of Antibiotics on Terrestrial Organisms.Antibiotics (Basel, Switzerland) · 2023Review
- The Age of Next-Generation Therapeutic-Microbe Discovery: Exploiting Microbe-Microbe and Host-Microbe Interactions for Disease Prevention.Infection and immunity · 2022Review
- A Peek into the Bacterial Microbiome of the Eurasian Red Squirrel (Animals : an open access journal from MDPI · 2022Article
- Immunomodulatory and biological properties of helminth-derived small molecules: Potential applications in diagnostics and therapeutics.Frontiers in parasitology · 2022Review
- Social complexity as a driving force of gut microbiota exchange among conspecific hosts in non-human primates.Frontiers in integrative neuroscience · 2022Review
- Gut Microbiome Composition Abnormalities Determined Using High-Throughput Sequencing in Children With Tic Disorder.Frontiers in pediatrics · 2022Article
- Gut Microbiota Linked with Reduced Fear of Humans in Red Junglefowl Has Implications for Early Domestication.Advanced genetics (Hoboken, N.J.) · 2021Article
- Microbiomes of clownfish and their symbiotic host anemone converge before their first physical contact.Microbiome · 2021Article
- Evolutionary Significance of the Neuroendocrine Stress Axis on Vertebrate Immunity and the Influence of the Microbiome on Early-Life Stress Regulation and Health Outcomes.Frontiers in microbiology · 2021Review
- Menstruation: science and society.American journal of obstetrics and gynecology · 2020Review
- The role of the microbiome in the neurobiology of social behaviour.Biological reviews of the Cambridge Philosophical Society · 2020Article
- The evolution of paternal care: a role for microbes?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Proteomics and Metabolomics Approaches towards a Functional Insight onto AUTISM Spectrum Disorders: Phenotype Stratification and Biomarker Discovery.International journal of molecular sciences · 2020Review
- TheFrontiers in psychology · 2020Article
- The concept of the hologenome, an epigenetic phenomenon, challenges aspects of the modern evolutionary synthesis.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2019Article
- Systems biology perspective for studying the gut microbiota in human physiology and liver diseases.EBioMedicine · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The tight association of the human body with trillions of colonizing microbes that we observe today is the result of a long evolutionary history. Only very recently have we started to understand how this symbiosis also affects brain function and behavior. In this hypothesis and theory article, we propose how host-microbe associations potentially influenced mammalian brain evolution and development. In particular, we explore the integration of human brain development with evolution, symbiosis, and RNA biology, which together represent a "social triangle" that drives human social behavior and cognition. We argue that, in order to understand how inter-kingdom communication can affect brain adaptation and plasticity, it is inevitable to consider epigenetic mechanisms as important mediators of genome-microbiome interactions on an individual as well as a transgenerational time scale. Finally, we unite these interpretations with the hologenome theory of evolution. Taken together, we propose a tighter integration of neuroscience fields with host-associated microbiology by taking an evolutionary perspective.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.