Evidence map›Paper›PMID 25401083›Full record

ArticleCurrent opinion in insect science2014

Effects of ingested vertebrate-derived factors on insect immune responses.

Nazzy Pakpour, Michael A Riehle, Shirley Luckhart

Open access · greenAbstract read
In one paragraph

Article in Current opinion in insect science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Chemical modulation of IMD signaling in the cat flea (Current research in insect science · 2026
    Article
  3. Article
  4. Article
  5. Viruses · 2022
    Article
  6. Article
  7. Frontiers in physiology · 2022
    Article
  8. Article
  9. Article
  10. Vector Specificity of Arbovirus Transmission.Frontiers in microbiology · 2021
    Review
  11. Review
  12. Article
  13. Last-come, best served? Mosquito biting order andProceedings. Biological sciences · 2020
    Article
  14. Article
  15. Transcriptome of theInternational journal of molecular sciences · 2020
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Nazzy PakpourDepartment of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, California, 95616.
Michael A RiehleDepartment of Entomology, University of Arizona, Tucson, Arizona 85721.
Shirley LuckhartDepartment of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, California, 95616.
University of California, Davis · USUniversity of Arizona · US

Funding

Systems biology approach to MAPK regulation of malaria infection in A. stephensiR01AI080799 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LUCKHART, SHIRLEY, VODOVOTZ, YORAM · 2009 to 2013
$3.4M
An.gambiae immune signaling gene SNPs and natural P. falciparum infectionR01AI078183 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LANZARO, GREGORY C., LUCKHART, SHIRLEY · 2010 to 2014
$3.2M
Insulin, IGF and Insulin Signaling: effects on Anopheles lifespan and immunityR01AI073745 · NIAID · UNIVERSITY OF ARIZONA · PI RIEHLE, MICHAEL ALLEN · 2008 to 2012
$2.5M
NIAID NIH HHS R01 AI073745NIAID NIH HHS R01 AI078183NIAID NIH HHS R01 AI080799
6 · The paper itself

Abstract

During the process of blood feeding insect vectors are exposed to an array of vertebrate-derived blood factors ranging from byproducts of blood meal digestion to naturally occurring products in the blood including growth hormones, cytokines and factors derived from blood-borne pathogens themselves. In this review, we examine the ability of these ingested vertebrate blood factors to alter the innate pathogen defenses of insect vectors. The ability of these factors to modify the immune responses of insect vectors offers new intriguing targets for blocking or reducing transmission of human disease-causing pathogens.

Indexed as

chitinasecomplementinsulininsulin-like growth factor 1 (IGF1)LeishmaniamosquitoPlasmodiumReduviidaesand flytransforming growth factor-beta (TGF-β)tsetse fly

Identifiers

PMID25401083
PMCPMC4228800
OpenAlexW2012468402

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.