ArticleBiomedical optics express2014
Optical coherence Doppler tomography for quantitative cerebral blood flow imaging.
Article in Biomedical optics express, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Cortical layer multi-parameter analysis of neurovascular impairments in AD/ADRD rodent model with in vivo optical imaging.Translational neurodegeneration · 2025Article
- Inhibition of iNOS reduced cerebral vasoconstriction from chronic cocaine and enhanced angiogenesis in the prefrontal cortex.Brain research bulletin · 2025Article
- Evidence of cortical vascular impairments in early stage of Alzheimer's transgenic mice: Optical imaging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Review of cocaine-induced brain vascular and cellular function changes measuredNeurophotonics · 2025Review
- Neurovascular effects of cocaine: relevance to addiction.Frontiers in pharmacology · 2024Review
- Article
- Impairment of cerebral vascular reactivity and resting blood flow in early-staged transgenic AD mice:Research square · 2023Article
- Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain.International journal of molecular sciences · 2023Article
- Dynamic 3D imaging of cerebral blood flow in awake mice using self-supervised-learning-enhanced optical coherence Doppler tomography.Communications biology · 2023Article
- Article
- Cocaine-induced ischemia in prefrontal cortex is associated with escalation of cocaine intake in rodents.Molecular psychiatry · 2020Article
- Electrically tunable lens integrated with optical coherence tomography angiography for cerebral blood flow imaging in deep cortical layers in mice.Optics letters · 2019Article
- A Mechanistic and Pathophysiological Approach for Stroke Associated with Drugs of Abuse.Journal of clinical medicine · 2019Review
- Spatial and Temporal Heterogeneities of Capillary Hemodynamics and Its Functional Coupling During Neural Activation.IEEE transactions on medical imaging · 2019Article
- Integrated multimodal photoacoustic microscopy with OCT- guided dynamic focusing.Biomedical optics express · 2019Article
- Doppler OCT clutter rejection using variance minimization and offset extrapolation.Biomedical optics express · 2018Article
- Long-term optical imaging of neurovascular coupling in mouse cortex using GCaMP6f and intrinsic hemodynamic signals.NeuroImage · 2018Article
- Robust numerical phase stabilization for long-range swept-source optical coherence tomography.Journal of biophotonics · 2017Article
- Quantitative angle-insensitive flow measurement using relative standard deviation OCT.Applied physics letters · 2017Article
- Volumetric Doppler angle correction for ultrahigh-resolution optical coherence Doppler tomography.Applied physics letters · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Optical coherence Doppler tomography (ODT) is a promising neurotechnique that permits 3D imaging of the cerebral blood flow (CBF) network; however, quantitative CBF velocity (CBFv) imaging remains challenging. Here we present a simple phase summation method to enhance slow capillary flow detection sensitivity without sacrificing dynamic range for fast flow and vessel tracking to improve angle correction for absolute CBFv quantification. Flow phantom validation indicated that the CBFv quantification accuracy increased from 15% to 91% and the coefficient of variation (CV) decreased 9.3-fold; in vivo mouse brain validation showed that CV decreased 4.4-/10.8- fold for venular/arteriolar flows. ODT was able to identify cocaine-elicited microischemia and quantify CBFv disruption in branch vessels and capillaries that otherwise would have not been possible.
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Registered trials
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