ReviewWorld journal of gastrointestinal oncology2014
Vitamin D and colon cancer.
Review in World journal of gastrointestinal oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Vitamin D and adrenal gland: Myth or reality? A systematic review.Frontiers in endocrinology · 2022Pooled it
- Correlation between polymorphism of vitamin D receptor TaqI and susceptibility to colorectal cancer: A meta-analysis.Medicine · 2017Pooled it
- Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data.PloS one · 2017Pooled it
- Association of Vitamin D Intake,Medical sciences (Basel, Switzerland) · 2026Article
- Association Between Serum Vitamin D Levels and Colorectal Carcinoma: Insights from a Case Control Study in Northern Saudi Arabia.Life (Basel, Switzerland) · 2026Article
- Emerging risk factors and the role of gut microbiota in immunomodulation and therapeutic implications in colorectal cancer.Cancer pathogenesis and therapy · 2026Review
- Increased Vitamin D Receptor Immunoreactivity in Endometrial Polyps: An Exploratory Single-Center Pilot Study.Cureus · 2025Article
- Vitamins A and D and Their Combinations for Breast and Colorectal Cancers: Analysis of the Clinical, Epidemiological, Preclinical and Transcriptomic Data.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Vitamin D-induced mechanisms in cancer prevention and therapy: Recent advances and future opportunities.Animal models and experimental medicine · 2025Review
- Vitamin D in Disease Prevention and Cure-Part I: An Update on Molecular Mechanism and Significance on Human Health.Indian journal of clinical biochemistry : IJCB · 2025Review
- Review
- Unraveling colorectal cancer prevention: The vitamin D - gut flora - immune system nexus.World journal of gastrointestinal oncology · 2024Review
- Osteoporosis Is Associated with an Increased Risk of Colorectal Neoplasms Regardless of Sex: Nationwide Population-Based Cohort Study.Diagnostics (Basel, Switzerland) · 2024Article
- Vitamin D and potential effects on cancers: a review.Molecular biology reports · 2024Review
- Potential association between arsenic and vitamin D.Frontiers in endocrinology · 2024Article
- Prevalence and risk factors of osteopenia in adults with short bowel syndrome: a retrospective longitudinal cohort study.Frontiers in medicine · 2024Article
- Vitamin D metabolism in cancer: potential feasibility of vitamin D metabolism blocking therapy.Medical molecular morphology · 2023Review
- Dry Eye Disease: What Is the Role of Vitamin D?International journal of molecular sciences · 2023Review
- Vitamin D and Colorectal Cancer: Current Perspectives and Future Directions.Journal of cancer prevention · 2022Review
- Pleiotropic Effects of Vitamin D in Patients with Inflammatory Bowel Diseases.Journal of clinical medicine · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcitriol, 1α, 25-dihydroxyvitamin D3 (1,25 (OH)2D3), the most active form of vitamin D, is a pleotropic hormone with a wide range of biological activities. Due to its ability to regulate calcium and phosphate metabolism, 1,25D3 plays a major role in bone health. In addition, 1,25D3 binds to the vitamin D receptor and thereby regulates the expression of a number of genes which control growth, differentiation and survival of cancer cells. In agreement, the levels of vitamin D3 appear to be an essential determinant for the development and progression of colon cancer and supplementation with vitamin D3 is effective in suppressing intestinal tumorigenesis in animal models. Vitamin D3 has been estimated to lower the incidence of colorectal cancer by 50%, which is consistent with the inverse correlation between dietary vitamin D3 intake or sunlight exposure and human colorectal cancer. Several studies confirmed that increasing vitamin D3 lowers colon cancer incidence, reduces polyp recurrence, and that sufficient levels of vitamin D3 are associated with better overall survival of colon cancer patients. Vitamin D regulates the homeostasis of intestinal epithelium by modulating the oncogenic Wnt signaling pathway and by inhibiting tumor-promoting inflammation. Both activities contribute to the ability of 1,25D3 to prevent the development and progression of colon cancer.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.