ArticleInternational journal of clinical and experimental pathology2014
Metabolomic profiling of human follicular fluid from patients with repeated failure of in vitro fertilization using gas chromatography/mass spectrometry.
Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Metabolomic alterations in follicular fluid across female infertility conditions in IVF: a systematic review.Journal of assisted reproduction and genetics · 2026Pooled it
- Metabolomics for improving pregnancy outcomes in women undergoing assisted reproductive technologies.The Cochrane database of systematic reviews · 2018Pooled it
- Metabolomics for improving pregnancy outcomes in women undergoing assisted reproductive technologies.The Cochrane database of systematic reviews · 2017Pooled it
- Serum Metabolomic Analysis of Synchronous Estrus in Yaks Based on UPLC-Q-TOF MS Technology.Animals : an open access journal from MDPI · 2024Article
- Metabolomic profiling of exosomes reveals age-related changes in ovarian follicular fluid.European journal of medical research · 2024Article
- Metabolomics and its applications in assisted reproductive technology.IET nanobiotechnology · 2023Review
- Dehydroepiandrosterone supplementation and the impact of follicular fluid metabolome and cytokinome profiles in poor ovarian responders.Journal of ovarian research · 2023Article
- Rapid and non-invasive diagnostic techniques for embryonic developmental potential: a metabolomic analysis based on Raman spectroscopy to identify the pregnancy outcomes of IVF-ET.Frontiers in cell and developmental biology · 2023Article
- Characterizing the follicular fluid metabolome: quantifying the correlation across follicles and differences with the serum metabolome.Fertility and sterility · 2022Article
- In vitro growth (IVG) of human ovarian follicles in frozen thawed ovarian cortex tissue culture supplemented with follicular fluid under hypoxic conditions.Archives of gynecology and obstetrics · 2022Article
- Correlation between Pre-Ovulatory Follicle Diameter and Follicular Fluid Metabolome Profiles in Lactating Beef Cows.Metabolites · 2021Article
- Altered Follicular Fluid Metabolic Pattern Correlates with Female Infertility and Outcome Measures of In Vitro Fertilization.International journal of molecular sciences · 2021Article
- Follicular Metabolites-Assisted Clinical Evaluation of IVF/ICSI Outcomes.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Human follicular fluid proteome reveals association between overweight status and oocyte maturation abnormality.Clinical proteomics · 2020Article
- NMR metabolic profiling of follicular fluid for investigating the different causes of female infertility: a pilot study.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Metabolomic profiling of ovary in mice treated with FSH using ultra performance liquid chromatography/mass spectrometry.Bioscience reports · 2018Article
- Follicular metabolic changes and effects on oocyte quality in polycystic ovary syndrome patients.Oncotarget · 2017Article
- Proteomic analysis of human follicular fluid associated with successful in vitro fertilization.Reproductive biology and endocrinology : RB&E · 2017Article
- Recent progress in metabolomics for analyzing common infertility conditions that affect ovarian function.Reproductive medicine and biologyReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo establish a gas chromatography/mass spectrometry (GC/MS)-based metabolomics method to compare the metabolites in the follicular fluid (FF) from patients with in vitro fertilization (IVF) and repeated IVF failure (RIF).
methodsA prospective study was employed in Center for Reprodutive Medcine, Renji Hospital, Shanghai, China, between January and October 2010. FF samples were collected from 13 patients with RIF and 15 patients who achieved pregnancy after the first IVF cycle.
resultsPartial least squares (PLS) discriminant analysis of the PCA data revealed that the samples were scattered into two different regions. FF from the two groups differed with respect to 20 metabolites. FF from RIF group showed elevated levels of several amino acids (valine, threonine, isoleucine, cysteine, serine, proline, alanine, phenylalanine, lysine, methionine and ornithine), and reduced levels of dicarboxylic acids, cholesterol and some organic acids.
conclusionsThe studies corroborated successful determination of the levels of metabolite in the FF.
Indexed as
Identifiers
25400819PMC4230118W259746414What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.