ArticleInternational journal of clinical and experimental pathology2014
Immunohistochemical characterization of brain-invasive meningiomas.
Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Prognostic significance of brain invasion in meningiomas: systematic review and meta-analysis.Brain tumor pathology · 2021Pooled it
- Brain invasion in meningiomas-clinical considerations and impact of neuropathological evaluation: a systematic review.Neuro-oncology · 2017Pooled it
- Correlation of Ki-67 and E-cadherin expression with tumor grade and brain invasion in meningiomas.Pakistan journal of medical sciences · 2026Article
- Application of the Mass Spectrometry-High-Throughput Technique Over the Immunohistochemical Analysis for Human Brain Tumor Diagnosis and Prognosis: Insights Into Biomarkers' Identification for the Case Study of Grade IV Astrocytomas and Meningiomas.Biomedical chromatography : BMC · 2025Article
- Atypical meningiomas with multiple extracranial metastases: a case description.Quantitative imaging in medicine and surgery · 2023Article
- Type IV collagen-derived angiogenesis inhibitor: canstatin low expressing in brain-invasive meningiomas using liquid chromatography-mass spectrometry (LC-MS/MS).Journal of neuro-oncology · 2023Article
- Updated Systematic Review on the Role of Brain Invasion in Intracranial Meningiomas: What, When, Why?Cancers · 2022Review
- Clinical and pathological impact of an optimal assessment of brain invasion for grade 2 meningioma diagnosis: lessons from a series of 291 cases.Neurosurgical review · 2022Article
- Molecular neuropathology of brain-invasive meningiomas.Brain pathology (Zurich, Switzerland) · 2022Review
- The Utility of Phosphohistone H3 in Inter-Observer Variability of Mitotic Count in Meningioma, is There Any Benefit?Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Brain-invasive meningiomas: molecular mechanisms and potential therapeutic options.Brain tumor pathology · 2021Review
- Review
- A radiomics model for preoperative prediction of brain invasion in meningioma non-invasively based on MRI: A multicentre study.EBioMedicine · 2020Article
- Absence of contrast enhancement in a petroclival meningioma: Case report and systematic literature review.Surgical neurology international · 2020Article
- Impact of postoperative radiotherapy on recurrence of primary intracranial atypical meningiomas.Journal of neuro-oncology · 2020Article
- A Quantified Risk-Scoring System for the Recurrence of Meningiomas: Results From a Retrospective Study of 392 Patients.Frontiers in oncology · 2020Article
- Meningioma Tumor Microenvironment.Advances in experimental medicine and biology · 2020Review
- Microscopic brain invasion in meningiomas previously classified as WHO grade I is not associated with patient outcome.Journal of neuro-oncology · 2019Article
- WHO grade of intracranial meningiomas differs with respect to patient's age, location, tumor size and peritumoral edema.Journal of neuro-oncology · 2019Observational
- Expression of Cathepsins B, D, and G in WHO Grade I Meningioma.Frontiers in surgery · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain-invasive meningiomas have an adverse prognosis, so it is important to detect and correctly evaluate brain invasion by light microscopy. Furthermore, the underlying biological mechanisms responsible for brain-invasive growth are incompletely understood. The primary aim of this study was to identify immunohistochemical markers that could improve identification and evaluation of brain invasion in meningiomas. A second aim was to investigate the process of brain invasion using immunohistochemical markers of proliferation, extracellular matrix modulation, and cell adhesion. From a series of 196 human meningiomas, 67 cases were selected for analysis because of the presence of brain tissue in tumor specimens. Fourteen of these 67 meningiomas were brain-invasive. Invasiveness was determined primarily by evaluation of hematoxylin-erytrosin-saffron- (HES-) stained specimens, although glial fibrillary acidic protein (GFAP), anti-collagen IV, and cluster of differentiation 44 (CD44) markers provided additional information. It was important to examine microscopic sections from various levels of the paraffin-embedded tissue block to adequately assess invasiveness. Sections stained using antibodies against Ki-67/MIB-1, phospohistone-H3 (PHH3), matrix metalloproteinase-9 (MMP-9), cathepsin D, plasminogen activator inhibitor-1 (PAI-1), and E-cadherin antigens were used to characterize brain-invasive meningiomas and to investigate the process of brain invasion. Only increased expression of the extracellular matrix modulator MMP-9 correlated with brain-invasive growth (p=0.025). Examination of HES-stained sections identified brain invasion. Use of relevant immunohistochemical markers did not contribute substantially to this evaluation. Evaluation of stepwise sections should be considered when brain-invasive growth is suspected. MMP-9 may be an important mediator of brain-invasive growth.
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25400818PMC4230100W2178599060What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.