Evidence map›Paper›PMID 25400785›Full record

ArticleInternational journal of clinical and experimental pathology2014

Tumor size of breast invasive ductal cancer measured with contrast-enhanced ultrasound predicts regional lymph node metastasis and N stage.

Zhiyuan Wang, Qichang Zhou, Jun Liu, Shichu Tang, Xia Liang, Zhengyu Zhou, Ying He, Hui Peng, Yuanming Xiao

Open access · greenAbstract read
In one paragraph

Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Zhiyuan WangDepartment of Ultrasound, The Second Xiangya Hospital of Central South University Changsha 410011, China ; Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University Changsha 410013, China.
Qichang ZhouDepartment of Ultrasound, The Second Xiangya Hospital of Central South University Changsha 410011, China.
Jun LiuDepartment of Radiology, The Second Xiangya Hospital of Central South University, The School of Public Administration of Central South University Changsha 410011, China.
Shichu TangDepartment of Ultrasound, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University Changsha 410013, China.
Xia LiangDepartment of Ultrasound, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University Changsha 410013, China.
Zhengyu ZhouDepartment of Ultrasound, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University Changsha 410013, China.
Ying HeDepartment of Breast Surgery, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University Changsha 410013, China.
Hui PengDepartment of Ultrasound, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University Changsha 410013, China.
Yuanming XiaoHealth Management Center, The Third Xiangya Hospital of Central South University Changsha 410013, China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to determine the role of breast invasive ductal cancer (BIDC) size measured with Contrast-enhanced Ultrasound (CEUS) in the prediction of regional lymph node metastasis (LNM) and N stage.

methodsOne hundred and six consecutive patients with breast lesions underwent ultrasound imaging within 2 weeks before mastectomy and axillary lymph node dissection. The largest transverse (width) and anteroposterior (depth) diameter were measured under CEUS by using calipers. The correlation between tumor size and regional LNM metastasis and N stage was evaluated.

resultsUnivariate analysis showed the diameters measured with CEUS were associated with lymph node metastasis (P < 0.05). The tumor size could distinguish grouped N stage (all P < 0.05). Tumor area (TA) might be an indicator that can differentiate No BIDC from N1-3 BIDC (cutoff = 5.37 cm(2)), N0-1 BIDC from N2-3 BIDC (cutoff = 6.48 cm(2)), and N0-2 BIDC from N3 BIDC (cutoff = 8.23 cm(2)) with the sensitivity of 71%, 72% and 83%, respectively, and the specificity of 79%, 68% and 84%, respectively.

conclusionsThe TA of BIDC measured with CEUS may be a predictor of regional LNM and N stage.

Indexed as

Contrast MediaPhospholipidsSulfur HexafluorideUltrasonography, MammaryAdultArea Under CurveBreast NeoplasmsCarcinoma, Ductal, BreastFemaleHumansLymphatic MetastasisMiddle AgedMultivariate AnalysisNeoplasm InvasivenessNeoplasm StagingObserver Variationcontrast agent BR1Contrast MediaPhospholipidsSulfur HexafluorideBreast invasive ductal cancercontrast-enhanced ultrasoundlymph node metastasisN stage

Identifiers

PMID25400785
PMCPMC4230066
OpenAlexW2274527296

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.