ArticleInternational journal of clinical and experimental pathology2014
miRNA-124 down-regulates SOX8 expression and suppresses cell proliferation in non-small cell lung cancer.
Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 10 papers.
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The trial behind it
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Who cites it
10 citing papers in PubMed, 36 citations in OpenAlex.
- Sox8: a multifaceted transcription factor in development and disease.Biology open · 2025Review
- Downregulation of SOX2 may be targeted by miR-590-5p and inhibits epithelial-to-mesenchymal transition in non-small-cell lung cancer.Experimental and therapeutic medicine · 2019Article
- Over-expression of SOX8 predicts poor prognosis in colorectal cancer: A retrospective study.Medicine · 2019Article
- Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- MicroRNA in Lung Cancer Metastasis.Cancers · 2019Review
- MiRNA-124 inhibits the proliferation, migration and invasion of cancer cell in hepatocellular carcinoma by downregulating lncRNA-UCA1.OncoTargets and therapy · 2019Article
- miR‑185 inhibits non‑small cell lung cancer cell proliferation and invasion through targeting of SOX9 and regulation of Wnt signaling.Molecular medicine reports · 2018Article
- Data mining and pathway analysis of glucose-6-phosphate dehydrogenase with natural language processing.Molecular medicine reports · 2017Article
- Extract of Spatholobus suberctus Dunn ameliorates ischemia-induced injury by targeting miR-494.PloS one · 2017Article
- Downregulation of miR-214-3p May Contribute to Pathogenesis of Ulcerative Colitis via Targeting STAT6.BioMed research international · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-small lung cell carcinoma (NSCLC) is a leading lethal disease and a global health burden. The function of the Sex determining region Y (SRY)-related high mobility group box (SOX) family gene in cancer has attracted the attention of more and more scientists recently, yet there are few reports regarding the role of SOX in NSCLC. Our study aimed to investigate the expression of SOX8, a protein belonging to the E group of the SOX family, as well as SOX9, in non-small cell lung cancer (NSCLC) and the relationship of gene expression to clinicopathological factors and prognosis in patients. Immunohistochemical analysis was used to measure the expression of SOX8 in 80 NSCLC and 7 adjacent normal tissues. SOX8 expression was detected as elevated in tumor samples and correlated to tumor size (P < 0.001), lymph node metastasis (P = 0.001), differentiation classification (P = 0.015), and clinical stage (P = 0.013) significantly. Moreover, Kaplan-Meier survival analysis demonstrated that shorter survival time for patients who had higher SOX8 expression (P < 0.001). In addition, our experiments indicate that miRNA-124 functions as a tumor suppressor in NSCLC. We also demonstrate miRNA-124 directly targeted and decreased SOX8 in NSCLC cell lines, suggesting smiRNA-124 may regulate NSCLC cell proliferation via decreasing SOX8 (oncogenicity of biomarker in NSCLC).
Indexed as
Identifiers
25400731PMC4230110W260354921What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.