Evidence map›Paper›PMID 25400705›Full record

ArticleJournal of neurodevelopmental disorders2014

EEG hyper-connectivity in high-risk infants is associated with later autism.

Elena V Orekhova, Mayada Elsabbagh, Emily Jh Jones, Geraldine Dawson, Tony Charman, Mark H Johnson, BASIS Team

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurodevelopmental disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 4 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 4 syntheses or guidelines pooled it, 216 citations in OpenAlex.

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  11. Behavioral Phenotype Associations With Resting State EEG Signal Complexity and Power Spectral Density in Fragile X Syndrome.Autism research : official journal of the International Society for Autism Research · 2026
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  15. Lower Cortical Activation and Altered Functional Connectivity Characterize Passive Auditory Spatial Attention in ASD.Autism research : official journal of the International Society for Autism Research · 2025
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Elena V OrekhovaCentre for Brain and Cognitive Development, School of Psychology, Birkbeck, University of London, Henry Welcome Building, London, WC1E 7HX UK.
Mayada ElsabbaghDepartment of Psychiatry, McGill University, Montreal, PQ H3A 1A1 Canada.
Emily Jh JonesCentre for Brain and Cognitive Development, School of Psychology, Birkbeck, University of London, Henry Welcome Building, London, WC1E 7HX UK.
Geraldine DawsonDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, NC 27705 USA.
Tony CharmanDepartment of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF UK.
Mark H JohnsonCentre for Brain and Cognitive Development, School of Psychology, Birkbeck, University of London, Henry Welcome Building, London, WC1E 7HX UK.
BASIS Team
Birkbeck, University of London · GBDuke University · USMcGill University · CAKing's College London · GB

Funding

Medical Research Council G0701484Medical Research Council MR/K021389/1
6 · The paper itself

Abstract

backgroundIt has been previously reported that structural and functional brain connectivity in individuals with autism spectrum disorders (ASD) is atypical and may vary with age. However, to date, no measures of functional connectivity measured within the first 2 years have specifically associated with a later ASD diagnosis.

methodsIn the present study, we analyzed functional brain connectivity in 14-month-old infants at high and low familial risk for ASD using electroencephalography (EEG). EEG was recorded while infants attended to videos. Connectivity was assessed using debiased weighted phase lag index (dbWPLI). At 36 months, the high-risk infants were assessed for symptoms of ASD.

resultsAs a group, high-risk infants who were later diagnosed with ASD demonstrated elevated phase-lagged alpha-range connectivity as compared to both low-risk infants and high-risk infants who did not go on to ASD. Hyper-connectivity was most prominent over frontal and central areas. The degree of hyper-connectivity at 14 months strongly correlated with the severity of restricted and repetitive behaviors in participants with ASD at 3 years. These effects were not attributable to differences in behavior during the EEG session or to differences in spectral power.

conclusionsThe results suggest that early hyper-connectivity in the alpha frequency range is an important feature of the ASD neurophysiological phenotype.

Indexed as

AlphaAutism spectrum disordersConnectivityEEGInfantsSiblings

Identifiers

PMID25400705
PMCPMC4232695
OpenAlexW2154205996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.