Is initial preservation of deep tendon reflexes in West Nile Virus paralysis a good prognostic sign?

Deb Kumar Mojumder, Melina Agosto, Henrik Wilms, Jongyeol Kim

Open access · greenAbstract read

In one paragraph

Article in Neurology Asia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.3field-weighted citation impact, top 29% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Deb Kumar MojumderDepartment of Neurology, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, Texas. USA.

Melina AgostoVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.

Henrik WilmsDepartment of Neurology, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, Texas. USA.

Jongyeol KimDepartment of Neurology, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, Texas. USA.

Baylor College of Medicine · US

Funding

RGS Protein Function in Mammalian RetinaR01EY011900 · NEI · BAYLOR COLLEGE OF MEDICINE · PI WENSEL, THEODORE G · 1998 to 2010

$4.4M

NEI NIH HHS R01 EY011900

6 · The paper itself

Abstract

Typical West Nile virus paralysis is characterized by muscle weakness, decreased tone, and loss of deep tendon reflexes attributed to destruction of anterior horn cells. Two cases in which deep tendon reflexes were initially preserved in the presence of profound and persistent muscle weakness are presented here. In both cases, deep tendon reflexes were later severely attenuated or lost, while weakness of the involved muscles remained profound and unchanged. Both patients showed good motor recovery at 6 months. Initial preservation of deep tendon reflexes in the presence of persistent muscle weakness indicates that in the early stages of disease, the muscle weakness in these two cases was not caused by destruction of anterior horn cells. Pathology involving anterior horns preceding AHC destruction could potentially disrupt upper motor neuron pathways to anterior horn cells, causing weakness with initial preserved deep tendon reflexes.

Identifiers

PMID25400704

PMCPMC4229851

OpenAlexW2188293171

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.