Evidence map›Paper›PMID 25400638›Full record

ReviewFrontiers in immunology2014

Aryl hydrocarbon receptor and kynurenine: recent advances in autoimmune disease research.

Nam Trung Nguyen, Taisuke Nakahama, Duc Hoang Le, Le Van Son, Ha Hoang Chu, Tadamitsu Kishimoto

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 4 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 4 syntheses or guidelines pooled it, 163 citations in OpenAlex.

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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Nam Trung NguyenLaboratory of Immune Regulation, WPI-Immunology Frontier Research Center, Osaka University , Suita , Japan ; National Key Laboratory of Gene Technology, Institute of Biotechnology, Vietnam Academy of Science and Technology , Hanoi , Vietnam.
Taisuke NakahamaLaboratory of Immune Regulation, WPI-Immunology Frontier Research Center, Osaka University , Suita , Japan ; Department of RNA Biology and Neuroscience, Graduate School of Medicine Osaka University , Suita , Japan.
Duc Hoang LeNational Key Laboratory of Gene Technology, Institute of Biotechnology, Vietnam Academy of Science and Technology , Hanoi , Vietnam.
Le Van SonNational Key Laboratory of Gene Technology, Institute of Biotechnology, Vietnam Academy of Science and Technology , Hanoi , Vietnam.
Ha Hoang ChuNational Key Laboratory of Gene Technology, Institute of Biotechnology, Vietnam Academy of Science and Technology , Hanoi , Vietnam.
Tadamitsu KishimotoLaboratory of Immune Regulation, WPI-Immunology Frontier Research Center, Osaka University , Suita , Japan.
Osaka University · JPVietnam Academy of Science and Technology · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aryl hydrocarbon receptor (AHR) is thought to be a crucial factor in the regulation of immune responses. Many AHR-mediated immunoregulatory mechanisms have been discovered, and this knowledge may enhance our understanding of the molecular pathogenesis of autoimmune inflammatory syndromes such as collagen-induced arthritis, experimental autoimmune encephalomyelitis, and experimental colitis. Recent findings have elucidated the critical link between AHR and indoleamine 2,3-dioxygenase (IDO) in the development of regulatory T cells and Th17 cells, which are key factors in a variety of human autoimmune diseases. Induction of IDO and IDO-mediated tryptophan catabolism, together with its downstream products such as kynurenine, is an important immunoregulatory mechanism underlying immunosuppression, tolerance, and immunity. Recent studies revealed that induction of IDO depends on AHR expression. This review summarizes the most current findings regarding the functions of AHR and IDO in immune cells as they relate to the pathogenesis of autoimmune diseases in response to various stimuli. We also discuss the potential link between AHR and IDO/tryptophan metabolites, and the involvement of several novel related factors (such as microRNA) in the development of autoimmune diseases. These novel factors represent potential therapeutic targets for the treatment of autoimmune disorders.

Indexed as

autoimmunitydioxin receptorimmune regulationindoleamine 2,3-dioxygenasetranscription factor

Identifiers

PMID25400638
PMCPMC4212680
OpenAlexW2089370088

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.