ReviewFrontiers in physiology2014
Stem cells can form gap junctions with cardiac myocytes and exert pro-arrhythmic effects.
Review in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- Casein Kinase 1 Phosphomimetic Mutations Negatively Impact Connexin-43 Gap Junctions in Human Pluripotent Stem Cell-Derived Cardiomyocytes.Biomolecules · 2024Article
- Stem cell laden nano and micro collagen/PLGA bimodal fibrous patches for myocardial regeneration.Biomaterials research · 2022Article
- Arrhythmogenic risks of stem cell replacement therapy for cardiovascular diseases.Journal of cellular physiology · 2020Review
- Turning regenerative technologies into treatment to repair myocardial injuries.Journal of cellular and molecular medicine · 2020Review
- The Role of Membrane Capacitance in Cardiac Impulse Conduction: An Optogenetic Study With Non-excitable Cells Coupled to Cardiomyocytes.Frontiers in physiology · 2020Article
- Biologically active constituents of the secretome of human W8B2Scientific reports · 2018Article
- Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications.Pharmacological reviews · 2017Review
- Concise Review: Criteria for Chamber-Specific Categorization of Human Cardiac Myocytes Derived from Pluripotent Stem Cells.Stem cells (Dayton, Ohio) · 2017Review
- Modeling Electrophysiological Coupling and Fusion between Human Mesenchymal Stem Cells and Cardiomyocytes.PLoS computational biology · 2016Article
- New therapies for reducing post-myocardial left ventricular remodeling.Annals of translational medicine · 2015Article
- Excitation-contraction coupling of human induced pluripotent stem cell-derived cardiomyocytes.Frontiers in cell and developmental biology · 2015Review
- Slow conduction in mixed cultured strands of primary ventricular cells and stem cell-derived cardiomyocytes.Frontiers in cell and developmental biology · 2015Article
- Editorial: Cardiac electronic remodeling and susceptibility to arrhythmias: an introduction and brief historical overview.Frontiers in physiology · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stem cell therapy has been suggested to be a promising option for regeneration of injured myocardium, for example following a myocardial infarction. For clinical use cell-based therapies have to be safe and applicable and are aimed to renovate the architecture of the heart. Yet for functional and coordinated activity synchronized with the host myocardium stem cells have to be capable of forming electrical connections with resident cardiomyocytes. In this paper we discuss whether stem cells are capable of establishing functional electrotonic connections with cardiomyocytes and whether these may generate a risk for arrhythmias. Application of stem cells in the clinical setting with outcomes concerning arrhythmogenic safety and future perspectives will also briefly be touched upon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.