ArticleFrontiers in systems neuroscience2014
Grid cell firing patterns may arise from feedback interaction between intrinsic rebound spiking and transverse traveling waves with multiple heading angles.
Article in Frontiers in systems neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Bifurcation of spiking oscillations from a center in resonate-and-fire neurons.Biological cybernetics · 2026Article
- Relative phase of membrane potential theta oscillations between individual hippocampal neurons code space.bioRxiv : the preprint server for biology · 2025Article
- Simulation of oscillatory dynamics induced by an approximation of grid cell output.Reviews in the neurosciences · 2023Review
- Gated transformations from egocentric to allocentric reference frames involving retrosplenial cortex, entorhinal cortex, and hippocampus.Hippocampus · 2023Review
- Article
- The Role of Hierarchical Dynamical Functions in Coding for Episodic Memory and Cognition.Journal of cognitive neuroscience · 2019Article
- Neural mechanisms of navigation involving interactions of cortical and subcortical structures.Journal of neurophysiology · 2018Review
- Interaction of Norepinephrine and Glucocorticoids Modulate Inhibition of Principle Cells of Layer II Medial Entorhinal Cortex in Male Mice.Frontiers in synaptic neuroscience · 2018Article
- An Analysis of Waves Underlying Grid Cell Firing in the Medial Enthorinal Cortex.Journal of mathematical neuroscience · 2017Article
- Distinct Functional Groups Emerge from the Intrinsic Properties of Molecularly Identified Entorhinal Interneurons and Principal Cells.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Critical Points and Traveling Wave in Locomotion: Experimental Evidence and Some Theoretical Considerations.Frontiers in neural circuits · 2017Review
- Modelling effects on grid cells of sensory input during self-motion.The Journal of physiology · 2016Review
- Potential roles of cholinergic modulation in the neural coding of location and movement speed.Journal of physiology, Paris · 2016Review
- Article
- Rebound spiking in layer II medial entorhinal cortex stellate cells: Possible mechanism of grid cell function.Neurobiology of learning and memory · 2016Article
- The Art of Grid Fields: Geometry of Neuronal Time.Frontiers in neural circuits · 2016Article
- Rebound spiking properties of mouse medial entorhinal cortex neurons in vivo.The European journal of neuroscience · 2015Article
- Current questions on space and time encoding.Hippocampus · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
This article presents a model using cellular resonance and rebound properties to model grid cells in medial entorhinal cortex. The model simulates the intrinsic resonance properties of single layer II stellate cells with different frequencies due to the hyperpolarization activated cation current (h current). The stellate cells generate rebound spikes after a delay interval that differs for neurons with different resonance frequency. Stellate cells drive inhibitory interneurons to cause rebound from inhibition in an alternate set of stellate cells that drive interneurons to activate the first set of cells. This allows maintenance of activity with cycle skipping of the spiking of cells that matches recent physiological data on theta cycle skipping. The rebound spiking interacts with subthreshold oscillatory input to stellate cells or interneurons regulated by medial septal input and defined relative to the spatial location coded by neurons. The timing of rebound determines whether the network maintains the activity for the same location or shifts to phases of activity representing a different location. Simulations show that spatial firing patterns similar to grid cells can be generated with a range of different resonance frequencies, indicating how grid cells could be generated with low frequencies present in bats and in mice with knockout of the HCN1 subunit of the h current.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.