ReviewFrontiers in cellular neuroscience2014
Translating neuronal activity at the synapse: presynaptic calcium sensors in short-term plasticity.
Review in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Microglial TNFα orchestrates protein phosphorylation in the cortex during the sleep period and controls homeostatic sleep.The EMBO journal · 2023Article
- Review
- Presynaptic Short-Term Plasticity Persists in the Absence of PKC Phosphorylation of Munc18-1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- Function of Drosophila Synaptotagmins in membrane trafficking at synapses.Cellular and molecular life sciences : CMLS · 2021Review
- Unc13: a multifunctional synaptic marvel.Current opinion in neurobiology · 2019Review
- Effect of adenosine on short-term synaptic plasticity in mouse piriform cortex in vitro: adenosine acts as a high-pass filter.Physiological reports · 2019Article
- Presynaptic GCaMP expression decreases vesicle release probability at the calyx of Held.Synapse (New York, N.Y.) · 2018Article
- Analog Signaling With the "Digital" Molecular Switch CaMKII.Frontiers in computational neuroscience · 2018Article
- A Calcium- and Diacylglycerol-Stimulated Protein Kinase C (PKC), Caenorhabditis elegans PKC-2, Links Thermal Signals to Learned Behavior by Acting in Sensory Neurons and Intestinal Cells.Molecular and cellular biology · 2017Article
- Article
- Molecular Basis for Modulation of Metabotropic Glutamate Receptors and Their Drug Actions by Extracellular CaInternational journal of molecular sciences · 2017Review
- Article
- Superpriming of synaptic vesicles as a common basis for intersynapse variability and modulation of synaptic strength.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Ion mobility-enhanced MS(E)-based label-free analysis reveals effects of low-dose radiation post contextual fear conditioning training on the mouse hippocampal proteome.Journal of proteomics · 2016Article
- Calcium sensor regulation of the CaV2.1 Ca2+ channel contributes to short-term synaptic plasticity in hippocampal neurons.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Presynaptic Adenosine Receptor-Mediated Regulation of Diverse Thalamocortical Short-Term Plasticity in the Mouse Whisker Pathway.Frontiers in neural circuits · 2016Article
- Fast kinetics of calcium signaling and sensor design.Current opinion in chemical biology · 2015Review
- Platelet Activating Factor Enhances Synaptic Vesicle Exocytosis Via PKC, Elevated Intracellular Calcium, and Modulation of Synapsin 1 Dynamics and Phosphorylation.Frontiers in cellular neuroscience · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
The complex manner in which patterns of presynaptic neural activity are translated into short-term plasticity (STP) suggests the existence of multiple presynaptic calcium (Ca(2+)) sensors, which regulate the amplitude and time-course of STP and are the focus of this review. We describe two canonical Ca(2+)-binding protein domains (C2 domains and EF-hands) and define criteria that need to be met for a protein to qualify as a Ca(2+) sensor mediating STP. With these criteria in mind, we discuss various forms of STP and identify established and putative Ca(2+) sensors. We find that despite the multitude of proposed sensors, only three are well established in STP: Munc13, protein kinase C (PKC) and synaptotagmin-7. For putative sensors, we pinpoint open questions and potential pitfalls. Finally, we discuss how the molecular properties and modes of action of Ca(2+) sensors can explain their differential involvement in STP and shape net synaptic output.
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