Observational studyWorld journal of gastroenterology2014
Higher vitamin D serum concentration increases health related quality of life in patients with inflammatory bowel diseases.
Observational study in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 61 citations in OpenAlex.
- Adequate vitamin D is associated with favorable disease outcome in children with inflammatory bowel disease receiving anti-tumor necrosis factor alpha therapy.Journal of pediatric gastroenterology and nutrition · 2026Article
- Vitamin D in mucosal healing: therapeutic potential and current evidence in inflammatory bowel disease.Therapeutic advances in gastroenterology · 2026Review
- Vitamin D status in Faroese adults and its association with inflammatory bowel diseases - a cross-sectional study from the FarGen 2 project.International journal of circumpolar health · 2025Article
- Impact of Etanercept on Vitamin D Status and Vitamin D-binding Protein in Bio-naïve Patients with Psoriasis.Acta dermato-venereologica · 2021Observational
- Article
- Sarcopenia and Vitamin D Deficiency in Patients with Crohn's Disease: Pathological Conditions That Should Be Linked Together.Nutrients · 2021Review
- Seasonal changes of circulating 25-hydroxyvitamin D correlate with the lower gut microbiome composition in inflammatory bowel disease patients.Scientific reports · 2020Article
- Higher 25-hydroxyvitamin D levels are associated with greater odds of remission with anti-tumour necrosis factor-α medications among patients with inflammatory bowel diseases.Alimentary pharmacology & therapeutics · 2017Article
- Low Serum Vitamin D During Remission Increases Risk of Clinical Relapse in Patients With Ulcerative Colitis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2017Article
- Vitamin D/VDR, Probiotics, and Gastrointestinal Diseases.Current medicinal chemistry · 2017Review
- Care of inflammatory bowel disease patients in remission.Gastroenterology report · 2016Review
- Protective links between vitamin D, inflammatory bowel disease and colon cancer.World journal of gastroenterology · 2016Review
- Diet and nutritional factors in inflammatory bowel diseases.World journal of gastroenterology · 2016Review
- Advances in nutritional therapy in inflammatory bowel diseases: Review.World journal of gastroenterology · 2016Review
- Vitamin D Deficiency Associated with Disease Activity in Patients with Inflammatory Bowel Diseases.Digestive diseases and sciences · 2015Article
- The Role of Vitamin D in Inflammatory Bowel Disease.Healthcare (Basel, Switzerland) · 2015Review
- Vitamin D associates with improved quality of life in participants with irritable bowel syndrome: outcomes from a pilot trial.BMJ open gastroenterology · 2015Article
- Vitamin D and inflammatory bowel disease.BioMed research international · 2015Review
- Association of Vitamin D Status and Clinical Outcome in Dogs with a Chronic Enteropathy.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effect of vitamin D (VD) concentrations and VD supplementation on health related quality of life in inflammatory bowel disease (IBD) patients.
methodsA cohort of 220 IBD patients including 141 Crohn's disease (CD) and 79 ulcerative colitis (UC) patients was followed-up at a tertiary IBD center. A subgroup of the cohort (n = 26) took VD supplements for > 3 mo. Health related quality of life was assessed using the short IBD questionnaire (sIBDQ). VD serum concentration and sIBDQ score were assessed between August and October 2012 (summer/autumn period) and between February and April 2013 (winter/spring period). The mean VD serum concentration and its correlation with disease activity of CD were determined for each season separately. In a subgroup of patients, the effects of VD supplementation on winter VD serum concentration, change in VD serum concentration from summer to winter, and winter sIBDQ score were analyzed.
resultsDuring the summer/autumn and the winter/spring period, 28% and 42% of IBD patients were VD-deficient (< 20 ng/mL), respectively. In the winter/spring period, there was a significant correlation between sIBDQ score and VD serum concentration in UC patients (r = 0.35, P = 0.02), with a trend towards significance in CD patients (r = 0.17, P = 0.06). In the winter/spring period, VD-insufficient patients (< 30 ng/mL) had a significantly lower mean sIBDQ score than VD-sufficient patients; this was true of both UC (48.3 ± 2.3 vs 56.7 ± 3.4, P = 0.04) and CD (55.7 ± 1.25 vs 60.8 ± 2.14, P = 0.04) patients. In all analyzed scenarios (UC/CD, the summer/autumn period and the winter/spring period), health related quality of life was the highest in patients with VD serum concentrations of 50-59 ng/mL. Supplementation with a median of 800 IU/d VD day did not influence VD serum concentration or the sIBDQ score.
conclusionVD serum concentration correlated with health related quality of life in UC and CD patients during the winter/spring period.
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