ReviewWorld journal of gastroenterology2014
Extrahepatic complications to cirrhosis and portal hypertension: haemodynamic and homeostatic aspects.
Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 82 citations in OpenAlex.
- Renal function and oxygenation are impaired early after liver transplantation despite hyperdynamic systemic circulation.Critical care (London, England) · 2017Trial
- On the History of Hepatic Vein Catheterization.Liver international : official journal of the International Association for the Study of the Liver · 2026Review
- A Prospective Observational Study on Renal Resistive Index as an Early Predictor of Hepatorenal Syndrome.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026Article
- Navigating TIPS in the era of ageing and metabolic comorbidity: a contemporary narrative review of risk, resilience, and outcomes.Gastroenterology report · 2026Review
- Article
- Chronic liver disease impacting the severity of acute pancreatitis: a detailed narrative review of the literature.Frontiers in gastroenterology (Lausanne, Switzerland) · 2026Review
- Article
- Liver and systemic hemodynamics in cirrhotic children.World journal of hepatology · 2025Review
- Vasomics of the liver.Gut · 2025Review
- Review
- Galectin-3 and Severity of Liver Fibrosis in Metabolic Dysfunction-Associated Fatty Liver Disease.Protein and peptide letters · 2024Review
- Cirrhotic cardiomyopathy: a subject that's always topical.Future science OA · 2024Article
- A case of chronic schistosomiasis in a Dongola stallion (Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2023Article
- Is Cirrhotic Cardiomyopathy Related to Cirrhosis Severity?Rambam Maimonides medical journal · 2023Article
- The Prevalence and Predictors of Restless Legs Syndrome in Patients with Liver Cirrhosis.Healthcare (Basel, Switzerland) · 2022Article
- Cervicocerebral atherosclerosis and its hepatic and coronary risk factors in patients with liver cirrhosis.Clinical and molecular hepatology · 2022Article
- Portal vein thrombosis and renal dysfunction: a national comparative study of liver transplant recipients for NAFLD versus alcoholic cirrhosis.Transplant international : official journal of the European Society for Organ Transplantation · 2021Article
- Cirrhotic Cardiomyopathy: The Interplay Between Liver and Cardiac Muscle. How Does the Cardiovascular System React When the Liver is Diseased?Current cardiology reviews · 2021Review
- Muscle-Invasive Bladder Cancer in Patients with Liver Cirrhosis: A Review of Pertinent Considerations.Bladder cancer (Amsterdam, Netherlands) · 2021Review
- Quantitative evaluation of hepatic integrin αEJNMMI research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In addition to complications relating to the liver, patients with cirrhosis and portal hypertension develop extrahepatic functional disturbances of multiple organ systems. This can be considered a multiple organ failure that involves the heart, lungs, kidneys, the immune systems, and other organ systems. Progressive fibrosis of the liver and subsequent metabolic impairment leads to a systemic and splanchnic arteriolar vasodilatation. This affects both the haemodynamic and functional homeostasis of many organs and largely determines the course of the disease. With the progression of the disease, the circulation becomes hyperdynamic with cardiac, pulmonary as well as renal consequences for dysfunction and reduced survival. Infections and a changed cardiac function known as cirrhotic cardiomyopathy may be involved in further aggravation of other complications such as renal failure precipitating the hepatorenal syndrome. Patients with end-stage liver disease and related complications as for example the hepatopulmonary syndrome can only radically be treated by liver transplantation. As a bridge to this treatment, knowledge on the mechanisms of the pathophysiology of complications is essential for the choice of vasoactive drugs, antibiotics, drugs with specific effects on fibrogenesis and inflammation, and drugs that target specific receptors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.