ArticleJournal of pharmacy & bioallied sciences2014
Detection of AdeABC efflux pump genes in tetracycline-resistant Acinetobacter baumannii isolates from burn and ventilator-associated pneumonia patients.
Article in Journal of pharmacy & bioallied sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Review
- Correlation of RND efflux pump expression and AdeRS mutations in tigecycline-resistant Acinetobacter baumannii from Thai clinical isolates.European journal of microbiology & immunology · 2024Article
- Genotypic Patterns of Multidrug-ResistantAdvanced biomedical research · 2023Review
- The frequency of efflux pump genes expression in Acinetobacter baumannii isolates from pulmonary secretions.AMB Express · 2022Article
- Whole-Genome Sequencing of a Colistin-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Efflux Pump Activity and Mutations Driving Multidrug Resistance inInternational journal of microbiology · 2021Article
- Antibiotic resistance assessment of Acinetobacter baumannii isolates from Tehran hospitals due to the presence of efflux pumps encoding genes (adeA and adeS genes) by molecular method.BMC research notes · 2020Article
- Tetracycline resistance mediated by tet efflux pumps in clinical isolates of Acinetobacter baumannii.Revista do Instituto de Medicina Tropical de Sao Paulo · 2020Article
- Role of efflux pumps in reduced susceptibility to tigecycline inNew microbes and new infections · 2019Article
- Interpretation for practice guidelines for prevention, diagnosis, and treatment of ventilator-associated pneumonia in burn patients by american burn association.Burns & trauma · 2015Review
- Role of Efflux Pumps in Reduced Susceptibility to Tigecycline among Clinical Isolates ofInternational journal of applied & basic medical researchArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAcinetobacter baumannii is the most prevalent nosocomial pathogen which have been emerged in the past three decades worldwide. The aim of this study was to assess the distribution of the AdeABC efflux pump genes, associated with tetracycline resistance in Acinetobacter baumannii isolates collected from burn infection and Ventilator Associated Pneumonia (VAP). MATERIALS AND
methodsNinety-eight A. baumannii isolates were collected from two different hospitals in Tehran, Iran. Tetracycline susceptibility testing was performed by disk diffusion and agar dilution methods according to the CLSI guidelines. The presence of adeSR, adeB, drug efflux system genes in resistant isolates was assessed by polymerase chain reaction (PCR). Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) was used as a chemical inhibitor agent to assess the contribution of AdeABC efflux pump in tetracycline resistance isolates.
resultsApproximately 48% (47 out of 98) of isolates showed resistance to tetracycline which 14 (14.2%) isolates were corresponded to burn infection and the remaining 33 (33.8%) strains were isolated from VAP. All tetracycline resistant isolates have AdeABC in PCR assay. The reduction of tetracycline MICs by using 50 μg/ml CCCP were as follows: in 18 isolates 2-4 fold reduction in MICs, 26 isolates showed 8 fold reduction,1 isolate showed 16 fold, 1 isolate showed 32 fold and the remaining 1 isolate showed 128 fold reduction in MICs.
conclusionThe results showed significant correlation between tetracycline resistance and AdeABC efflux pump genes in resistant A. baumannii isolates.
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