Evidence map›Paper›PMID 25400315›Full record

SynthesisDisease markers2014

Prediabetes is associated with HNF-4 α P2 promoter polymorphism rs1884613: a case-control study in Han Chinese population and an updated meta-analysis.

Changyi Wang, Sihan Chen, Tao Zhang, Zhongwei Chen, Shengyuan Liu, Xiaolin Peng, Jianping Ma, Xiaohong Zhong, Yanqiong Yan, Linlin Tang and 3 more

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Disease markers, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Genetic Variants ofGenes · 2023
    Article
  2. Association Analysis of the HNF4A Common Genetic Variants with Type 2 Diabetes Mellitus Risk.International journal of molecular and cellular medicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Changyi WangShenzhen Nanshan Center for Chronic Disease Control, Shenzhen 518054, China.
Sihan ChenShenzhen Nanshan Center for Chronic Disease Control, Shenzhen 518054, China.
Tao ZhangShenzhen Nanshan Center for Chronic Disease Control, Shenzhen 518054, China.
Zhongwei ChenShenzhen Nanshan Center for Chronic Disease Control, Shenzhen 518054, China.
Shengyuan LiuShenzhen Nanshan Center for Chronic Disease Control, Shenzhen 518054, China.
Xiaolin PengShenzhen Nanshan Center for Chronic Disease Control, Shenzhen 518054, China.
Jianping MaShenzhen Nanshan Center for Chronic Disease Control, Shenzhen 518054, China.
Xiaohong ZhongShenzhen Shekou People's Hospital, Shenzhen 518067, China.
Yanqiong YanShenzhen Shekou People's Hospital, Shenzhen 518067, China.
Linlin TangThe Affiliated Hospital, School of Medicine, Ningbo University, Ningbo, Zhejiang 315000, China.
Yifeng MaiThe Affiliated Hospital, School of Medicine, Ningbo University, Ningbo, Zhejiang 315000, China.
Liyuan HanSchool of Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Diabetes Center, Ningbo University, Ningbo 315211, China.
Shiwei DuanSchool of Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Diabetes Center, Ningbo University, Ningbo 315211, China.ORCID 0000-0001-7682-2877
Shenzhen Nanshan Center for Chronic Disease Control · CNNingbo University · CNShenZhen People’s Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundControversy remains for the association between hepatocyte nuclear factor 4α (HNF-4α) P2 promoter polymorphism rs1884613 and type 2 diabetes (T2D). There was no association test of this polymorphism with prediabetes and T2D in the Chinese population. Moreover, an updated meta-analysis in various ethnic groups is needed to establish the contribution of rs1884613 to T2D risk.

methodsUsing the Sequenom MassARRAY platform approach, we genotyped rs1884613 of HNF-4α in the P2 promoter region among 490 T2D patients, 471 individuals with prediabetes, and 575 healthy controls. All the individuals were recruited from 16 community health service centers in Nanshan district in Shenzhen province. Using STATA 11.0 software, meta-analysis was performed to summarize the overall contribution of rs1884613 to T2D risk.

resultsPolymorphism rs1884613 was associated with genetic susceptibility to prediabetes in the whole samples (OR = 1.40, 95% CI = 1.16-1.68, P = 0.0001) and the female subgrouped samples (OR = 1.48, 95% CI = 1.14-1.92, P = 0.003) after adjusting for age and body mass index (BMI). In contrast, there was no association of rs1884613 with T2D in the whole samples and male in our case-control study and meta-analysis.

conclusionsOur results suggest that rs1884613 contributes to susceptibility to prediabetes, whereas this polymorphism may not play an important role in the development of T2D.

Indexed as

Polymorphism, Single NucleotidePromoter Regions, GeneticAgedCase-Control StudiesDiabetes Mellitus, Type 2FemaleHepatocyte Nuclear Factor 4HumansMaleMiddle AgedPrediabetic StateHepatocyte Nuclear Factor 4HNF4A protein, human

Identifiers

PMID25400315
PMCPMC4226192
OpenAlexW1973837277

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.