ArticleMacromolecules2014
Optimizing the Selectivity of Surface-Adsorbing Multivalent Polymers.
Article in Macromolecules, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- Amplification Free Detection of SARS-CoV-2 Using Multi-Valent Binding.ACS sensors · 2022Article
- Density Control over MBD2 Receptor-Coated Surfaces Provides Superselective Binding of Hypermethylated DNA.ACS applied materials & interfaces · 2022Article
- Biophysical Considerations in the Rational Design and Cellular Targeting of Flexible Polymeric Nanoparticles.Advanced materials interfaces · 2021Article
- Multiscale modeling of protein membrane interactions for nanoparticle targeting in drug delivery.Current opinion in structural biology · 2020Review
- Article
- Computational design of probes to detect bacterial genomes by multivalent binding.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Strong Selective Adsorption of Polymers.Macromolecules · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multivalent polymers are macromolecules containing multiple chemical moieties designed to bind to complementary moieties on a target; for example, a protein with multiple ligands that have affinity for receptors on a cell surface. Though the individual ligand-receptor bonds are often weak, the combinatorial entropy associated with the different possible ligand-receptor pairs leads to a binding transition that can be very sharp with respect to control parameters, such as temperature or surface receptor concentration. We use mean-field self-consistent field theory to study the binding selectivity of multivalent polymers to receptor-coated surfaces. Polymers that have their ligands clustered into a contiguous domain, either located at the chain end or chain midsection, exhibit cooperative surface adsorption and superselectivity when the polymer concentration is low. On the other hand, when the ligands are uniformly spaced along the chain backbone, selectivity is substantially reduced due to the lack of binding cooperativity and due to crowding of the surface by the inert polymer segments in the chain backbone.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.