Evidence map›Paper›PMID 25400119›Full record

ArticleOncotarget2014

Tamoxifen represses alcohol-induced transcription of RNA polymerase III-dependent genes in breast cancer cells.

Qian Zhong, Ganggang Shi, Qingsong Zhang, Lei Lu, Daniel Levy, Shuping Zhong

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
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  6. Article
  7. Alcohol Intake and Abnormal Expression of Brf1 in Breast Cancer.Oxidative medicine and cellular longevity · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Qian ZhongDepartment of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, China.
Ganggang ShiShantou University Medical College, Shantou, Guangdong, China.
Qingsong ZhangDepartment of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lei LuDepartment of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Daniel LevyDepartment of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Shuping ZhongDepartment of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Shantou University Medical College, Shantou, Guangdong, China.
University of Southern California · USShantou University · CNSun Yat-sen University Cancer Center · CN

Funding

Mechanism of Alcohol-induced RNA pol III dependent transcriptionR21AA017288 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHONG, SHUPING · 2009 to 2010
$447k
Function of Runx2 in alcohol-associated breast cancerR21AA023247 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHONG, SHUPING · 2014 to 2015
$446k
Role of MSK1, ERa and Brf1 in alcohol-associated breast cancerR21AA021114 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHONG, SHUPING · 2012 to 2013
$434k
NIAAA NIH HHS AA017288NIAAA NIH HHS AA021114NIAAA NIH HHS AA023247NIAAA NIH HHS R21 AA017288NIAAA NIH HHS R21 AA021114NIAAA NIH HHS R21 AA023247
6 · The paper itself

Abstract

Alcohol consumption in women has been associated with an increased risk of breast cancer, particular in estrogen receptor positive (ER+) cases. Deregulation of RNA polymerase III-dependent (Pol III) transcription enhances cellular tRNAs and 5S rRNA production, leading to an increase in translational capacity to promote cell transformation and tumor formation. Our recent studies demonstrated that alcohol induces Brf1 expression and Pol III gene transcription via ER. Here, we report that Tamoxifen (Tam) inhibits the induction of Brf1 and Pol III genes in ER+ breast cancer cells. Further analysis indicates that alcohol increases c-Jun expression to upregulate the transcription of Brf1 and Pol III genes, whereas Tam reduces c-Jun expression to repress the transcription of Brf1. Repression of cJun decreases cellular levels of ERα and Brf1. Alcohol-dependent increased occupancy of Brf1 in Pol III gene promoters is reduced by Tam. The repression of Brf1 and Pol III genes by Tam reduces alcohol-induced cell proliferation and colony formation. Together, these results indicate that Tam inhibits alcohol-induced Brf1 expression through c-Jun and ERα to downregulate Pol III gene transcription. Our studies uncover a new mechanism of Tam-treated ER+ breast cancer, by which Tam inhibits tumor growth through repressing Pol III gene transcription.

Indexed as

Blotting, WesternBreast NeoplasmsCell Line, TumorCell ProliferationChromatin ImmunoprecipitationEthanolGene Expression Regulation, NeoplasticHumansReal-Time Polymerase Chain ReactionReceptors, EstrogenRNA Polymerase IIISignal TransductionTamoxifenTATA-Binding Protein Associated FactorsTransfectionBRF1 protein, humanEthanolReceptors, EstrogenRNA Polymerase IIITamoxifenTATA-Binding Protein Associated Factors

Identifiers

PMID25400119
PMCPMC4322994
OpenAlexW2169166216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.