ArticleScientific reports2014
Periostin suppression induces decorin secretion leading to reduced breast cancer cell motility and invasion.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- A label-free microLC-SWATH-MS methodology with immunoaffinity depletion of highly abundant serum proteins for quantitative proteomic comparison of fresh-frozen human normal breast tissue and tumor clinical specimens.Frontiers in molecular biosciences · 2026Article
- Article
- Soluble Periostin is a potential surveillance biomarker for early and long-term response to chemotherapy in advanced breast cancer.Cancer cell international · 2024Article
- Preclinical Research of Stem Cells: Challenges and Progress.Stem cell reviews and reports · 2023Review
- Soluble POSTN is a novel biomarker complementing CA153 and CEA for breast cancer diagnosis and metastasis prediction.BMC cancer · 2022Article
- Periostin is a novel histological biomarker for the diagnosis of chondroid tumor.Translational cancer research · 2021Article
- Osteoblasts are "educated" by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment.Breast cancer research : BCR · 2019Article
- False discovery rate control for high dimensional networks of quantile associations conditioning on covariates.Journal of the Royal Statistical Society. Series B, Statistical methodology · 2018Article
- Rapid proteomic analysis for solid tumors reveals LSD1 as a drug target in an end-stage cancer patient.Molecular oncology · 2018Article
- Charting the unexplored extracellular matrix in cancer.International journal of experimental pathology · 2018Review
- Periostin silencing suppresses the aggressive phenotype of thyroid carcinoma cells by suppressing the Akt/thyroid stimulating hormone receptor axis.Cytotechnology · 2018Article
- Surface functionalization of electrospun scaffolds using recombinant human decorin attracts circulating endothelial progenitor cells.Scientific reports · 2018Article
- The interplay between extracellular matrix remodelling and kinase signalling in cancer progression and metastasis.Cell adhesion & migration · 2018Review
- Competing endogenous RNA network analysis identifies critical genes among the different breast cancer subtypes.Oncotarget · 2017Article
- A Timely Shift from Shotgun to Targeted Proteomics and How It Can Be Groundbreaking for Cancer Research.Frontiers in oncology · 2017Review
- Raised mammographic density: causative mechanisms and biological consequences.Breast cancer research : BCR · 2016Review
- Periostin expression in intra-tumoral stromal cells is prognostic and predictive for colorectal carcinoma via creating a cancer-supportive niche.Oncotarget · 2016Article
- Prognostic value of stromal decorin expression in patients with breast cancer: a meta-analysis.Journal of thoracic disease · 2015Article
- Periostin: its role in asthma and its potential as a diagnostic or therapeutic target.Respiratory research · 2015Review
- Decorin: A Growth Factor Antagonist for Tumor Growth Inhibition.BioMed research international · 2015Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability of cancer cells to metastasize is dependent on the interactions between their cell-surface molecules and the microenvironment. However, the tumor microenvironment, especially the cancer-associated stroma, is poorly understood. To identify proteins present in the stroma, we focused on phyllodes tumors, rare breast tumors that contain breast stromal cells. We compared the expression of proteins between phyllodes tumor and normal tissues using an iTRAQ-based quantitative proteomic approach. Decorin was expressed at reduced levels in phyllodes tumor tissues, whereas periostin was upregulated; this result was validated by immunohistochemical analysis of phyllodes tumors from 35 patients. Additionally, by immunoprecipitation and mass spectrometry, we confirmed that decorin forms a complex with periostin in both phyllodes tumors and BT-20 breast cancer cells. Following siRNA-mediated knockdown of periostin in T-47D cells, secreted decorin in the culture medium could be detected by multiple reaction monitoring (MRM). Furthermore, periostin knockdown in BT-20 cells and overexpression of decorin in MDA-MB-231 cells inhibited cell motility and invasion. Our results reveal the molecular details of the periostin-decorin complex in both phyllodes tumor tissues and breast cancer cells; this interaction may represent a novel target for anti-cancer therapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.