Evidence map›Paper›PMID 25400073›Full record

ReviewMolecular oral microbiology2015

Breaking the bacterial protein targeting and translocation model: oral organisms as a case in point.

N E Lewis, L J Brady

Open access · greenAbstract readReview
In one paragraph

Review in Molecular oral microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Cytoplasmic Domains ofFrontiers in microbiology · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Journal of bacteriology · 2019
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

N E LewisDepartment of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, USA.
L J Brady
University of Florida · US

Funding

MEMBRANES OF THE DENTAL PATHOGEN STREPTOCOCCUS MUTANSR01DE008007 · NIDCR · UNIVERSITY OF FLORIDA · PI L. Jeannine Brady, Surabhi Mishra · 1986 to 2026
$8.6M
Comprehensive Training Program in Oral BiologyT90DE021990 · NIDCR · UNIVERSITY OF FLORIDA · PI Jose A Lemos · 2011 to 2026
$8.2M
NIDCR NIH HHS 1T90DE021990NIDCR NIH HHS R01 DE008007NIDCR NIH HHS T90 DE021990
6 · The paper itself

Abstract

Insights into the membrane biogenesis of oral and throat bacteria have highlighted key differences in protein localization by the general secretion pathway compared with the well-studied Escherichia coli model system. These intriguing novelties have advanced our understanding of both how these microorganisms have adapted to survive and cause disease in the oral cavity, and the field of protein translocation as a whole. This review focuses on findings that highlight where oral bacteria differ from the E. coli paradigm, why these differences are biologically important, and what questions remain about the differences in pathway function. The majority of insight into protein translocation in microbes of the oral cavity has come from streptococcal species, which will be the main topic of this review. However, other bacteria will be discussed when relevant. An overview of the E. coli model of protein targeting and translocation is provided for comparison.

Indexed as

Bacterial Secretion SystemsEscherichia coliEscherichia coli ProteinsMembrane Transport ProteinsModels, BiologicalMouthProtein TransportSignal Recognition ParticleBacterial Secretion SystemsEscherichia coli ProteinsMembrane Transport ProteinsSignal Recognition ParticleYIDC protein, E colimembrane biogenesisprotein secretionsignal recognition particletargetingtranslocationtransport

Identifiers

PMID25400073
PMCPMC4420647
OpenAlexW2050480322

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.