Evidence map›Paper›PMID 25399909›Full record

SynthesisCirculation. Heart failure2015

Exercise training in patients with heart failure and preserved ejection fraction: meta-analysis of randomized control trials.

Ambarish Pandey, Akhil Parashar, Dharam Kumbhani, Sunil Agarwal, Jalaj Garg, Dalane Kitzman, Benjamin Levine, Mark Drazner, Jarett Berry

2 registry-linked trialsOpen access · bronzeAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Circulation. Heart failure, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 263 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
263citing papers in PubMed, 12 pooled it
21.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05784753 narecruitingnot on this mapstarted 2023, after this paper: background citation

HEART (Heart Failure Exercise and Resistance Training) Camp Connect: Promoting Adherence to Exercise in Adults With Heart Failure With Preserved Ejection Fraction

TypeinterventionalSponsorUniversity of NebraskaRan2023 to 2028Enrolled300ConditionsHFpEF - Heart Failure With Preserved Ejection FractionArmsHEART Camp, HEART Camp Connect
NCT05888688 recruitingnot on this mapstarted 2023, after this paper: background citation

The Imaging Assessment of Sarcopenia Across the Heart Failure Spectrum

Typeobservational_patient_registrySponsorUniversity of LeicesterRan2023 to 2026Enrolled80ConditionsHeart Failure, Sarcopenia, Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction
3 · Its place in the literature

Who cites it

263 citing papers in PubMed, 12 syntheses or guidelines pooled it, 486 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Highlights in heart failure.ESC heart failure · 2019
    Pooled it
  12. Pooled it
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Feasibility and Outcomes of an Exercise Intervention for Chemotherapy-Induced Heart Failure.Journal of cardiopulmonary rehabilitation and prevention · 2019
    Trial
  18. Trial
  19. Trial
  20. Review

203 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Ambarish Pandey *Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, TX.
Akhil Parashar *Department of Internal Medicine, Cleveland Clinic, Cleveland, OH.
Dharam KumbhaniDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, TX.
Sunil AgarwalDivision of General Internal Medicine, Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Jalaj GargDivision of Cardiology, Lehigh Valley Health Network, Allentown, PA.
Dalane KitzmanDivision of Cardiology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC.
Benjamin LevineDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, TX.
Mark DraznerDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, TX.
Jarett BerryDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, TX.
Johns Hopkins Medicine · USJohns Hopkins University · USCleveland Clinic · USLehigh Valley Health Network · USLehigh Valley Hospital-Pocono · US

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamie Nicole Justice · 2002 to 2026
$36.4M
WORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUNDLEY, WILLIAM GREGORY · 1992 to 2010
$35.2M
REHAB-HF: A Trial of Rehabilitation Therapy in Older Acute Heart Failure PatientsR01AG045551 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2014 to 2018
$6.8M
Exercise Intolerance in Older HFPEF PatientsR01AG018915 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2001 to 2019
$5.2M
Exercise Intolerance in Elderly Diastolic Heart FailureR37AG018915 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2005 to 2013
$3.4M
NCRR NIH HHS M01 RR007122NIA NIH HHS P30 AG021332NIA NIH HHS R01 AG018915NIA NIH HHS R01 AG045551NIA NIH HHS R37 AG018915
6 · The paper itself

Abstract

backgroundHeart failure with preserved ejection fraction (HFPEF) is common and characterized by exercise intolerance and lack of proven effective therapies. Exercise training has been shown to be effective in improving cardiorespiratory fitness (CRF) in patients with systolic heart failure. In this meta-analysis, we aim to evaluate the effects of exercise training on CRF, quality of life, and diastolic function in patients with HFPEF. METHODS AND

resultsRandomized controlled clinical trials that evaluated the efficacy of exercise training in patients with HFPEF were included in this meta-analysis. Primary outcome of the study was change in CRF (measured as change in peak oxygen uptake). Effect of exercise training on quality of life (estimated using Minnesota living with heart failure score), and left ventricular systolic and diastolic function was also assessed. The study included 276 patients who were enrolled in 6 randomized controlled trials. In the pooled data analysis, patients with HFPEF undergoing exercise training had significantly improved CRF (mL/kg per min; weighted mean difference, 2.72; 95% confidence interval, 1.79-3.65) and quality of life (weighted mean difference, -3.97; 95% confidence interval, -7.21 to -0.72) when compared with the control group. However, no significant change was observed in the systolic function (EF-weighted mean difference, 1.26; 95% confidence interval, -0.13% to 2.66%) or diastolic function (E/A-weighted mean difference, 0.08; 95% confidence interval, -0.01 to 0.16) with exercise training in patients with HFPEF.

conclusionsExercise training in patients with HFPEF is associated with an improvement in CRF and quality of life without significant changes in left ventricular systolic or diastolic function.

Indexed as

Exercise ToleranceRandomized Controlled Trials as TopicStroke VolumeExercise TherapyHeart FailureHumansVentricular Function, Leftdiastolicexerciseheart failuremeta-analysisphysical fitness

Identifiers

PMID25399909
PMCPMC4792111
OpenAlexW2727980964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.