Evidence map›Paper›PMID 25398896›Full record

ArticleNucleic acids research2015

FlyBase: introduction of the Drosophila melanogaster Release 6 reference genome assembly and large-scale migration of genome annotations.

Gilberto dos Santos, Andrew J Schroeder, Joshua L Goodman, Victor B Strelets, Madeline A Crosby, Jim Thurmond, David B Emmert, William M Gelbart, FlyBase Consortium

Abstract read
In one paragraph

Article in Nucleic acids research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 297 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
297citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

297 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  8. Emergence Biases in Molecular Evolution.Genome biology and evolution · 2026
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  15. Leptin Acts as a Peripheral Tropic Signal to Tune Steroidogenesis.bioRxiv : the preprint server for biology · 2026
    Article
  16. AbioRxiv : the preprint server for biology · 2026
    Article
  17. Article
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  20. Article

237 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gilberto dos SantosThe Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA dossantos@morgan.harvard.edu.
Andrew J SchroederThe Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.
Joshua L GoodmanDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.
Victor B StreletsDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.
Madeline A CrosbyThe Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.
Jim ThurmondDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.
David B EmmertThe Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.
William M GelbartThe Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.
FlyBase Consortium

Funding

FLYBASE: A DROSOPHILA RELATIONAL DATABASEP41HG000739 · NHGRI · HARVARD UNIVERSITY · PI GELBART, WILLIAM MARTIN · 1992 to 2014
$56.6M
Resource Project CoreU41HG000739 · NHGRI · HARVARD UNIVERSITY · PI PERRIMON, NORBERT · 2014 to 2022
$32.3M
UNM Initiative to Maximize Student Diversity (IMSD)R25GM060201 · NIGMS · UNIVERSITY OF NEW MEXICO · PI WERNER-WASHBURNE, MARGRET C. · 2000 to 2017
$9.9M
Medical Research Council G1000968NHGRI NIH HHS P41 HG000739NHGRI NIH HHS U41 HG000739NHGRI NIH HHS U41 HG00739NIGMS NIH HHS R25 GM060201
6 · The paper itself

Abstract

Release 6, the latest reference genome assembly of the fruit fly Drosophila melanogaster, was released by the Berkeley Drosophila Genome Project in 2014; it replaces their previous Release 5 genome assembly, which had been the reference genome assembly for over 7 years. With the enormous amount of information now attached to the D. melanogaster genome in public repositories and individual laboratories, the replacement of the previous assembly by the new one is a major event requiring careful migration of annotations and genome-anchored data to the new, improved assembly. In this report, we describe the attributes of the new Release 6 reference genome assembly, the migration of FlyBase genome annotations to this new assembly, how genome features on this new assembly can be viewed in FlyBase (http://flybase.org) and how users can convert coordinates for their own data to the corresponding Release 6 coordinates.

Indexed as

Databases, GeneticGenome, InsectMolecular Sequence AnnotationAnimalsDrosophila melanogasterGenomicsHigh-Throughput Nucleotide SequencingInternetModels, GeneticMolecular Sequence DataReference StandardsSequence AlignmentSoftware

Identifiers

PMID25398896
PMCPMC4383921

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.