Evidence map›Paper›PMID 25398884›Full record

ArticleCarcinogenesis2015

Effect of preeclampsia on umbilical cord blood stem cells in relation to breast cancer susceptibility in the offspring.

Li Qiu, Sagano Onoyama, Hoi Pang Low, Chien-I Chang, William C Strohsnitter, Errol R Norwitz, Mary Lopresti, Kathryn Edmiston, Mats Lambe, Dimitrios Trichopoulos and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Carcinogenesis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Prenatal Maternal Physical Activity and Stem Cells in Umbilical Cord Blood.Medicine and science in sports and exercise · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Li QiuDepartment of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA, Department of Obstetrics and Gynecology, Tufts Medical Center, Boston, MA 02111, USA, Division of Hematology/Oncology, Department of Medicine, University of Massachusetts Medical School and UMass Memorial Health Care, Worcester, MA 01655, USA, Department of Medical Epidemiology and Biostatistics, Karolinska Institute, SE171 77 Stockholm, Sweden, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA and Department of Hygiene, Epidemiology, and Medical Statistics, University of Athens, 115 27 Athens, Greece.
Sagano OnoyamaDepartment of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA, Department of Obstetrics and Gynecology, Tufts Medical Center, Boston, MA 02111, USA, Division of Hematology/Oncology, Department of Medicine, University of Massachusetts Medical School and UMass Memorial Health Care, Worcester, MA 01655, USA, Department of Medical Epidemiology and Biostatistics, Karolinska Institute, SE171 77 Stockholm, Sweden, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA and Department of Hygiene, Epidemiology, and Medical Statistics, University of Athens, 115 27 Athens, Greece.
Hoi Pang LowDepartment of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA, Department of Obstetrics and Gynecology, Tufts Medical Center, Boston, MA 02111, USA, Division of Hematology/Oncology, Department of Medicine, University of Massachusetts Medical School and UMass Memorial Health Care, Worcester, MA 01655, USA, Department of Medical Epidemiology and Biostatistics, Karolinska Institute, SE171 77 Stockholm, Sweden, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA and Department of Hygiene, Epidemiology, and Medical Statistics, University of Athens, 115 27 Athens, Greece.
Chien-I ChangDepartment of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA, Department of Obstetrics and Gynecology, Tufts Medical Center, Boston, MA 02111, USA, Division of Hematology/Oncology, Department of Medicine, University of Massachusetts Medical School and UMass Memorial Health Care, Worcester, MA 01655, USA, Department of Medical Epidemiology and Biostatistics, Karolinska Institute, SE171 77 Stockholm, Sweden, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA and Department of Hygiene, Epidemiology, and Medical Statistics, University of Athens, 115 27 Athens, Greece.
William C StrohsnitterDepartment of Obstetrics and Gynecology, Tufts Medical Center, Boston, MA 02111, USA.
Errol R NorwitzDepartment of Obstetrics and Gynecology, Tufts Medical Center, Boston, MA 02111, USA.
Mary LoprestiDivision of Hematology/Oncology, Department of Medicine, University of Massachusetts Medical School and UMass Memorial Health Care, Worcester, MA 01655, USA.
Kathryn EdmistonDivision of Hematology/Oncology, Department of Medicine, University of Massachusetts Medical School and UMass Memorial Health Care, Worcester, MA 01655, USA.
Mats LambeDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, SE171 77 Stockholm, Sweden.
Dimitrios TrichopoulosDepartment of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA and.
Pagona LagiouDepartment of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA and Department of Hygiene, Epidemiology, and Medical Statistics, University of Athens, 115 27 Athens, Greece.
Chung-Cheng HsiehDepartment of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA, Department of Obstetrics and Gynecology, Tufts Medical Center, Boston, MA 02111, USA, Division of Hematology/Oncology, Department of Medicine, University of Massachusetts Medical School and UMass Memorial Health Care, Worcester, MA 01655, USA, Department of Medical Epidemiology and Biostatistics, Karolinska Institute, SE171 77 Stockholm, Sweden, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA and Department of Hygiene, Epidemiology, and Medical Statistics, University of Athens, 115 27 Athens, Greece chung-cheng.hsieh@umassmed.edu.
Tufts Medical Center · USHarvard University · USKarolinska Institutet · SE

Funding

Stem Cells and Perinatal Factors for Breast Cancer RiskR01CA090902 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HSIEH, CHUNG-CHENG · 2002 to 2011
$3.3M
NCI NIH HHS CA090902
6 · The paper itself

Abstract

Women born from a preeclamptic (PE) pregnancy are associated with a lower risk of breast cancer. Prenatal and early-life exposures are hypothesized to influence breast cancer susceptibility through their effect on stem cells. We examined stem cell populations in umbilical cord blood from PE pregnancies and compared with those from pregnancies without this condition. We isolated mononuclear cells from 58 PE and 197 normotensive (non-PE) umbilical cord blood samples and examined the different stem cell populations. Hematopoietic (CD34(+) and CD34(+)CD38(-)), endothelial (CD34(+)CD133(+), CD34(+)VEGFR2(+), CD133(+)VEGFR2(+) and CD34(+)CD133(+)VEGFR2(+)), and putative breast (EpCAM(+), EpCAM(+)CD49f(+), EpCAM(+)CD49f(+)CD117(+), CD49f(+)CD24(+), CD24(+)CD29(+) and CD24(+)CD29(+)CD49f(+)) stem/progenitor cell subpopulations were quantified by flow cytometry and compared between PE and non-PE samples. Hematopoietic CD34(+) cell counts were significantly lowered in PE compared with non-PE samples (P = 0.039, Kruskal-Wallis test). Levels of CD34(+)CD133(+) endothelial progenitor cells were also lower in PE samples (P = 0.032, multiple regression analysis). EpCAM(+) and EpCAM(+)CD49f(+) putative breast stem cell levels were significantly lowered in PE subjects (multiple regression analysis: P = 0.038 and 0.007, respectively). Stratifying by newborn gender, EpCAM(+) and EpCAM(+)CD49f(+) stem cells were significantly lowered in PE samples of female, but not male, newborns. Umbilical cord blood samples from pregnancies complicated by preeclampsia thus had significantly lower levels of hematopoietic, endothelial, and putative breast stem cells than non-PE controls. With a lowered breast cancer risk for offspring of a PE pregnancy, our findings provide support to the hypothesis that susceptibility to breast oncogenesis may be affected by conditions and processes during the prenatal period.

Indexed as

AdolescentAdultBreast NeoplasmsCells, CulturedDisease SusceptibilityFemaleFetal BloodFetal Stem CellsFlow CytometryHumansInfant, NewbornMalePre-EclampsiaPregnancyReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, Messenger

Identifiers

PMID25398884
PMCPMC4291050
OpenAlexW2106523483

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.