Evidence map›Paper›PMID 25398607›Full record

ArticleJournal of leukocyte biology2015

Macrophage migration inhibitory factor is required for recruitment of scar-associated macrophages during liver fibrosis.

Mark A Barnes, Megan R McMullen, Sanjoy Roychowdhury, Nabil Z Madhun, Kathryn Niese, Mitchell A Olman, Abram B Stavitsky, Richard Bucala, Laura E Nagy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of leukocyte biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 53 citations in OpenAlex.

  1. Reprogramming macrophages to treat liver diseases.Hepatology (Baltimore, Md.) · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Macrophage heterogeneity in liver fibrosis.Frontiers in immunology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mark A BarnesDepartments of *Molecular Medicine and Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA; Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; and Departments of Pathobiology and Gastroenterology and Hepatology, Center for Liver Disease Research, Cleveland Clinic, Cleveland, Ohio, USA.
Megan R McMullenDepartments of *Molecular Medicine and Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA; Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; and Departments of Pathobiology and Gastroenterology and Hepatology, Center for Liver Disease Research, Cleveland Clinic, Cleveland, Ohio, USA.
Sanjoy RoychowdhuryDepartments of *Molecular Medicine and Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA; Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; and Departments of Pathobiology and Gastroenterology and Hepatology, Center for Liver Disease Research, Cleveland Clinic, Cleveland, Ohio, USA.
Nabil Z MadhunDepartments of *Molecular Medicine and Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA; Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; and Departments of Pathobiology and Gastroenterology and Hepatology, Center for Liver Disease Research, Cleveland Clinic, Cleveland, Ohio, USA.
Kathryn NieseDepartments of *Molecular Medicine and Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA; Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; and Departments of Pathobiology and Gastroenterology and Hepatology, Center for Liver Disease Research, Cleveland Clinic, Cleveland, Ohio, USA.
Mitchell A OlmanDepartments of *Molecular Medicine and Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA; Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; and Departments of Pathobiology and Gastroenterology and Hepatology, Center for Liver Disease Research, Cleveland Clinic, Cleveland, Ohio, USA.
Abram B StavitskyDepartments of *Molecular Medicine and Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA; Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; and Departments of Pathobiology and Gastroenterology and Hepatology, Center for Liver Disease Research, Cleveland Clinic, Cleveland, Ohio, USA.
Richard BucalaDepartments of *Molecular Medicine and Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA; Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; and Departments of Pathobiology and Gastroenterology and Hepatology, Center for Liver Disease Research, Cleveland Clinic, Cleveland, Ohio, USA.
Laura E NagyDepartments of *Molecular Medicine and Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA; Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; and Departments of Pathobiology and Gastroenterology and Hepatology, Center for Liver Disease Research, Cleveland Clinic, Cleveland, Ohio, USA nagyL3@ccf.org.
Cleveland Clinic · USYale University · US

Funding

Role of Adipose in Ethanol-Induced Tissue InjuryR37AA011876 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI NAGY, LAURA E. · 2009 to 2018
$4.0M
MIF in progression and treatment of ALDU01AA020821 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI NAGY, LAURA E. · 2012 to 2016
$2.1M
Myofibroblast differentiation and fibrosis are mediated by TRPV4 mechanosensingR01HL119792 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI OLMAN, MITCHELL ALAN · 2014 to 2017
$1.6M
NHLBI NIH HHS R01 HL119792NIAAA NIH HHS R37 AA011876NIAAA NIH HHS U01 AA020821
6 · The paper itself

Abstract

Recruitment of peripheral monocytes to the liver is a key contributor to the response to injury. MIF can act as a chemokine and cytokine, regulating innate immune responses in many tissues and cell types. We hypothesized that MIF contributes to the progression of CCl4-induced hepatic fibrosis by regulating recruitment of SAM. SAMs dynamically regulate HSC activation and ECM degradation. To gain insight into the role of MIF in progression of liver fibrosis, we investigated markers of fibrosis and immune responses after chronic CCl4 administration to female C57BL/6 and MIF(-/-) mice. Chronic CCl4 exposure increased activation of HSC in WT mice, indicated by increased expression of αSMA mRNA and protein, as well as mRNA for collagen 1α1; these responses were blunted in female MIF(-/-) mice. Despite lower activation of HSC in MIF(-/-) mice, accumulation of ECM was similar in WT and MIF(-/-)mice, suggesting a decreased rate of ECM degradation. Recruitment of SAMs was lower in MIF(-/-) mice compared with WT mice, both in their initial inflammatory phenotype, as well as in the later phase as proresolution macrophages. The decreased presence of resolution macrophages was associated with lower expression of MMP13 in MIF(-/-) mice. Taken together, these data indicate that MIF-dependent recruitment of SAMs contributes to degradation of ECM via MMP13, highlighting the importance of appropriate recruitment and phenotypic profile of macrophages in the resolution of fibrosis.

Indexed as

AnimalsChemotaxis, LeukocyteCicatrixDisease Models, AnimalExtracellular MatrixFemaleFlow CytometryImmunoblottingImmunohistochemistryIntramolecular OxidoreductasesLiver CirrhosisMacrophage Migration-Inhibitory FactorsMacrophagesMaleMatrix Metalloproteinase 13MiceIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMatrix Metalloproteinase 13Mif protein, mouseMmp13 protein, mousecarbon tetrachlorideMIF

Identifiers

PMID25398607
PMCPMC4377826
OpenAlexW2059021156

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.