ArticleCalcified tissue international2015
Primary cilia exist in a small fraction of cells in trabecular bone and marrow.
Article in Calcified tissue international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Mechanobiological Response of Osteocyte TRPV4 Base on the Piezoelectricity of Bone Matrix.Annals of biomedical engineering · 2026Article
- Effects of microgravity mechanotransduction in bone tissue and cells: systematic review on primary cilium-dependent mechanisms.NPJ microgravity · 2026Article
- Osteocytes and Primary Cilia.Current osteoporosis reports · 2023Review
- The Effect of IFT80 Deficiency in Osteocytes on Orthodontic Loading-Induced and Physiologic Bone Remodeling: In Vivo Study.Life (Basel, Switzerland) · 2022Article
- Mechanical regulation of bone remodeling.Bone research · 2022Review
- The effects of locomotion on bone marrow mesenchymal stem cell fate: insight into mechanical regulation and bone formation.Cell & bioscience · 2021Review
- The Skeletal Cellular and Molecular Underpinning of the Murine Hindlimb Unloading Model.Frontiers in physiology · 2021Review
- Molecular mechanosensors in osteocytes.Bone research · 2020Review
- Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling.Cell death & disease · 2019Article
- Physical Activity and Bone Health: What Is the Role of Immune System? A Narrative Review of the Third Way.Frontiers in endocrinology · 2019Review
- Why the impact of mechanical stimuli on stem cells remains a challenge.Cellular and molecular life sciences : CMLS · 2018Review
- Mechanical loading disrupts osteocyte plasma membranes which initiates mechanosensation events in bone.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Functional Diversity of Ciliary Proteins in Bone Development and Disease.Current osteoporosis reports · 2017Review
- Bone: A Fertile Soil for Cancer Metastasis.Current drug targets · 2017Review
- Primary Cilia and Intraflagellar Transport Proteins in Bone and Cartilage.Journal of dental research · 2016Review
- Mechanical signals promote osteogenic fate through a primary cilia-mediated mechanism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Primary cilia are potent mechanical and chemical sensory organelles in cells of bone lineage in tissue culture. Cell culture experiments suggest that primary cilia sense fluid flow and this stimulus is translated through biochemical signaling into an osteogenic response in bone cells. Moreover, in vivo, primary cilia knockout in bone cells attenuates bone formation in response to loading. However, understanding the role of the primary cilium in bone mechanotransduction requires knowledge of its incidence and location in vivo. We used immunohistochemistry to quantify the number of cells with primary cilia within the trabecular bone tissue and the enclosed marrow of ovine cervical vertebrae. Primary cilia were identified in osteocytes, bone lining cells, and in cells within the marrow, but were present in only a small fraction of cells. Approximately 4% of osteocytes and 4.6% of bone lining cells expressed primary cilia. Within the marrow space, only approximately 1% of cells presented primary cilia. The low incidence of primary cilia may indicate that cilia either function as mechanosensors in a selected number of cells, function in concert with other mechanosensing mechanisms, or that the role of primary cilia in mechanosensing is secondary to its role in chemosensing or cellular attachment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.