ArticleThe Journal of physiology2015
Leptin differentially increases sympathetic nerve activity and its baroreflex regulation in female rats: role of oestrogen.
Article in The Journal of physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 47 citations in OpenAlex.
- Cardiometabolic regulation by adipocyte-derived leptin and the brain melanocortin system.Clinical science (London, England : 1979) · 2026Review
- Neural and hormonal mechanisms of appetite regulation during eating.Frontiers in nutrition · 2025Review
- Influence of Leptin on the Secretion of Growth Hormone in Ewes under Different Photoperiodic Conditions.International journal of molecular sciences · 2023Article
- Leptin Increases: Physiological Roles in the Control of Sympathetic Nerve Activity, Energy Balance, and the Hypothalamic-Pituitary-Thyroid Axis.International journal of molecular sciences · 2023Review
- The role of the autonomic nervous system in polycystic ovary syndrome.Frontiers in endocrinology · 2023Review
- Central Nervous System Actions of Leptin Improve Cardiac Function After Ischemia-Reperfusion: Roles of Sympathetic Innervation and Sex Differences.Journal of the American Heart Association · 2022Article
- Jin-Tian-Ge ameliorates ovariectomy-induced bone loss in rats and modulates osteoblastogenesis and osteoclastogenesis in vitro.Chinese medicine · 2022Article
- Loss of the Protective Effect of Estrogen Contributes to Maternal Gestational Hypertension-Induced Hypertensive Response Sensitization Elicited by Postweaning High-Fat Diet in Female Offspring.Journal of the American Heart Association · 2022Article
- Modulation of Sirt1 and FoxO1 on Hypothalamic Leptin-Mediated Sympathetic Activation and Inflammation in Diet-Induced Obese Rats.Journal of the American Heart Association · 2021Article
- Review
- Article
- Comparison of high-fat style diet-induced dysregulation of baroreflex control of renal sympathetic nerve activity in intact and ovariectomized female rats: Renal sympathetic nerve activity in high-fat style diet fed intact and ovariectomized female rats.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- Obesity: sex and sympathetics.Biology of sex differences · 2020Review
- Sites and sources of sympathoexcitation in obese male rats: role of brain insulin.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Adaptations in autonomic nervous system regulation in normal and hypertensive pregnancy.Handbook of clinical neurology · 2020Review
- Resistance to the sympathoexcitatory effects of insulin and leptin in late pregnant rats.The Journal of physiology · 2019Article
- Sex differences in the sympathoexcitatory response to insulin in obese rats: role of neuropeptide Y.The Journal of physiology · 2019Article
- Sex Differences in Mechanisms of Hypertension Associated With Obesity.Hypertension (Dallas, Tex. : 1979) · 2018Review
- Factors Responsible for Obesity-Related Hypertension.Current hypertension reports · 2017Review
- Heart rate variability analysis during immediate recovery from exercise in overweight/obese healthy young adult females.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2017Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Obesity and hypertension are commonly associated, and activation of the sympathetic nervous system is considered to be a major contributor, at least in part due to the central actions of leptin. However, while leptin increases sympathetic nerve activity (SNA) in males, whether leptin is equally effective in females is unknown. Here, we show that intracerebroventricular (i.c.v.) leptin increases lumbar (LSNA) and renal (RSNA) SNA and baroreflex control of LSNA and RSNA in α-chloralose anaesthetized female rats, but only during pro-oestrus. In contrast, i.c.v. leptin increased basal and baroreflex control of splanchnic SNA (SSNA) and heart rate (HR) in rats in both the pro-oestrus and dioestrus states. The effects of leptin on basal LSNA, RSNA, SSNA and HR were similar in males and pro-oestrus females; however, i.c.v. leptin increased mean arterial pressure (MAP) only in males. Leptin did not alter LSNA or HR in ovariectomized rats, but its effects were normalized with 4 days of oestrogen treatment. Bilateral nanoinjection of SHU9119 into the paraventricular nucleus of the hypothalamus (PVN), to block α-melanocyte-stimulating hormone (α-MSH) type 3 and 4 receptors, decreased LSNA in leptin-treated pro-oestrus but not dioestrus rats. Unlike leptin, i.c.v. insulin infusion increased basal and baroreflex control of LSNA and HR similarly in pro-oestrus and dioestrus rats; these responses did not differ from those in male rats. We conclude that, in female rats, leptin's stimulatory effects on SNA are differentially enhanced by oestrogen, at least in part via an increase in α-MSH activity in the PVN. These data further suggest that the actions of leptin and insulin to increase the activity of various sympathetic nerves occur via different neuronal pathways or cellular mechanisms. These results may explain the poor correlation in females of SNA with adiposity, or of MAP with leptin.
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