ArticleThe Journal of infectious diseases2015
Transcriptional changes that characterize the immune reactions of leprosy.
Article in The Journal of infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 46 citations in OpenAlex.
- Tissue Expression of NGF in Skin Lesions of HIV-Coinfected and Non-Coinfected Leprosy Patients and Its Relationship with Leprosy Neural Damage.Microorganisms · 2025Article
- Unveiling genetic signatures associated with resilience to neonatal diarrhea in lambs through two GWAS approaches.Scientific reports · 2024Article
- Leprosy reactions: Unraveling immunological mechanisms underlying tissue damage in leprosy patients.Pathogens and disease · 2024Review
- Whole blood transcriptomics reveals the enrichment of neutrophil activation pathways during erythema nodosum leprosum reaction.Frontiers in immunology · 2024Article
- The Many Hosts of Mycobacteria 9 (MHM9): A conference report.Tuberculosis (Edinburgh, Scotland) · 2023Article
- Clinical, epidemiological, and laboratory prognostic factors in patients with leprosy reactions: A 10-year retrospective cohort study.Frontiers in medicine · 2022Article
- The Type I Interferon Pathway Is Upregulated in the Cutaneous Lesions and Blood of Multibacillary Leprosy Patients With Erythema Nodosum Leprosum.Frontiers in medicine · 2022Article
- Susceptibility and resistance in leprosy: Studies in the mouse model.Immunological reviews · 2021Review
- The Role of Complement System and the Immune Response to Tuberculosis Infection.Medicina (Kaunas, Lithuania) · 2021Review
- Host-Related Laboratory Parameters for Leprosy Reactions.Frontiers in medicine · 2021Review
- Changes in B Cell Pool of Patients With Multibacillary Leprosy: Diminished Memory B Cell and Enhanced Mature B in Peripheral Blood.Frontiers in immunology · 2021Article
- Neutrophil NETworking in ENL: Potential as a Putative Biomarker: Future Insights.Frontiers in medicine · 2021Review
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- Whole blood RNA signatures in leprosy patients identify reversal reactions before clinical onset: a prospective, multicenter study.Scientific reports · 2019Article
- Identification of a systemic interferon-γ inducible antimicrobial gene signature in leprosy patients undergoing reversal reaction.PLoS neglected tropical diseases · 2019Article
- Differential immunoglobulin and complement levels in leprosy prior to development of reversal reaction and erythema nodosum leprosum.PLoS neglected tropical diseases · 2019Article
- Immunometabolic Signatures Predict Risk of Progression to Active Tuberculosis and Disease Outcome.Frontiers in immunology · 2019Article
- Neutrophils in Leprosy.Frontiers in immunology · 2019Review
- Whole blood profiling of leprosy type 1(reversal) reactions highlights prominence of innate immune response genes.BMC infectious diseases · 2018Article
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundLeprosy morbidity is increased by 2 pathologic immune reactions, reversal reaction (RR) and erythema nodosum leprosum (ENL).
methodsTo discover host factors related to immune reactions, global transcriptional profiles of peripheral blood mononuclear cells were compared between 11 RR, 11 ENL, and 19 matched control patients, with confirmation by quantitative polymerase chain reaction. Encoded proteins were investigated in skin biopsy specimens by means of immunohistochemistry.
resultsThere were 275 genes differentially expressed in RR and 517 differentially expressed in ENL on the microarray. Pathway analysis showed immunity-related pathways represented in RR and ENL transcriptional profiles, with the "complement and coagulation" pathway common to both. Interferon γ was identified as a significant upstream regulator of the expression changes for RR and ENL. Immunohistochemical staining of skin lesions showed increased C1q in both RR and ENL.
conclusionsThese data suggest a previously underrecognized role for complement in the pathogenesis of both RR and ENL, and we propose new hypotheses for reaction pathogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.