Evidence map›Paper›PMID 25398216›Full record

ArticleEnvironmental science and pollution research international2015

Changes in protein expression of pacific oyster Crassostrea gigas exposed in situ to urban sewage.

Fabrício Flores-Nunes, Tânia Gomes, Rui Company, Roberta R M Moraes, Silvio T Sasaki, Satie Taniguchi, Márcia C Bicego, Cláudio M R Melo, Afonso C D Bainy, Maria J Bebianno

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Environmental science and pollution research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Ancient DNA from shells reveals delayed genomic erosion and rapid immune adaptation in the critically endangered black abalone.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Molecular and cellular effects of contamination in aquatic ecosystems.Environmental science and pollution research international · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Fabrício Flores-NunesLaboratory for Biomarkers of Aquatic Contamination and Immunochemistry, Federal University Santa Catarina, Florianópolis, Brazil.
Tânia GomesCIMA, Faculty of Science and Technology, University of Algarve, Campus de Gambelas, 8005-139, Faro, Portugal.
Rui CompanyCIMA, Faculty of Science and Technology, University of Algarve, Campus de Gambelas, 8005-139, Faro, Portugal.
Roberta R M MoraesLaboratory for Biomarkers of Aquatic Contamination and Immunochemistry, Federal University Santa Catarina, Florianópolis, Brazil.
Silvio T SasakiLaboratory of Marine Organic Chemistry, Oceanographic Institute, University of São Paulo, São Paulo, Brazil.
Satie TaniguchiLaboratory of Marine Organic Chemistry, Oceanographic Institute, University of São Paulo, São Paulo, Brazil.
Márcia C BicegoLaboratory of Marine Organic Chemistry, Oceanographic Institute, University of São Paulo, São Paulo, Brazil.
Cláudio M R MeloLaboratory of Marine Molluscs, Federal University of Santa Catarina, Florianópolis, Brazil.
Afonso C D BainyLaboratory for Biomarkers of Aquatic Contamination and Immunochemistry, Federal University Santa Catarina, Florianópolis, Brazil.
Maria J BebiannoCIMA, Faculty of Science and Technology, University of Algarve, Campus de Gambelas, 8005-139, Faro, Portugal. mbebian@ualg.pt.
Universidade de São Paulo · BRUniversidade Federal de Santa Catarina · BRUniversity of Algarve · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The composition and concentration of substances in urban effluents are complex and difficult to measure. These contaminants elicit biological responses in the exposed organisms. Proteomic analysis is a powerful tool in environmental toxicology by evidencing alterations in protein expression due to exposure to contaminants and by providing a useful framework for the development of new potential biomarkers. The aim of this study was to determine changes in protein expression signatures (PES) in the digestive gland of oysters Crassostrea gigas transplanted to two farming areas (LIS and RIB) and to one area contaminated by sanitary sewage (BUC) after 14 days of exposure. This species is one of the most cultivated molluscs in the world. The identified proteins are related to the cytoskeleton (CKAP5 and ACT2), ubiquitination pathway conjugation (UBE3C), G protein-coupled receptor and signal transduction (SVEP1), and cell cycle/division (CCNB3). CKAP5 showed higher expression in oysters kept at BUC in comparison with those kept at the farming areas, while ACT2, UBE3C, SVEP1, and CCNB3 were suppressed. The results suggest that these changes might lead to DNA damage, apoptosis, and interference with the immune system in oyster C. gigas exposed to sewage and give initial information on PES of C. gigas exposed to sanitary sewage, which can subsequently be useful in the development of more sensitive tools for biomonitoring coastal areas, particularly those devoted mainly to oyster farming activities.

Indexed as

CitiesAnimalsCrassostreaEnvironmental MonitoringEnvironmental PollutantsProteinsSewageTranscriptomeEnvironmental PollutantsProteinsSewageCrassostrea gigasProteomic analysisTwo-dimensional gel electrophoresisUrban sewage

Identifiers

PMID25398216
OpenAlexW1980251157

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.