Evidence map›Paper›PMID 25398200›Full record

ReviewSeminars in immunopathology2015

Novel insights into host-fungal pathogen interactions derived from live-cell imaging.

Judith Bain, Neil A R Gow, Lars-Peter Erwig

Open access · hybridAbstract readReview
In one paragraph

Review in Seminars in immunopathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Article
  3. The pathobiology of human fungal infections.Nature reviews. Microbiology · 2024
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Microorganisms · 2021
    Article
  10. Article
  11. Review
  12. Article
  13. A Bright Future for Fluorescence Imaging of Fungi in Living Hosts.Journal of fungi (Basel, Switzerland) · 2019
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Visualizing the Early Stages of Phagocytosis.Journal of visualized experiments : JoVE · 2017
    Article
  19. Shedding light on biology of bacterial cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016
    Review
  20. Anti-Immune Strategies of Pathogenic Fungi.Frontiers in cellular and infection microbiology · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Judith BainAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UK.
Neil A R Gow
Lars-Peter Erwig
University of Aberdeen · GB

Funding

Chief Scientist Office SCD/03Wellcome Trust 075470Wellcome Trust 080088Wellcome Trust 086827Wellcome Trust 097377Wellcome Trust 099215Wellcome Trust 101873
6 · The paper itself

Abstract

The theoretical physicist and Nobel laureate Richard Feynman outlined in his 1959 lecture, "There's plenty of room at the bottom", the enormous possibility of producing and visualising things at smaller scales. The advent of advanced scanning and transmission electron microscopy and high-resolution microscopy has begun to open the door to visualise host-pathogen interactions at smaller scales, and spinning disc confocal and two-photon microscopy has improved our ability to study these events in real time in three dimensions. The aim of this review is to illustrate some of the advances in understanding host-fungal interactions that have been made in recent years in particular those relating to the interactions of live fungal pathogens with phagocytes. Dynamic imaging of host-pathogen interactions has recently revealed novel detail and unsuspected mechanistic insights, facilitating the dissection of the phagocytic process into its component parts. Here, we will highlight advances in our knowledge of host-fungal pathogen interactions, including the specific effects of fungal cell viability, cell wall composition and morphogenesis on the phagocytic process and try to define the relative contributions of neutrophils and macrophages to the clearance of fungal pathogens in vitro and the infected host.

Indexed as

AnimalsFungiHost-Pathogen InteractionsHumansImmunity, InnateMacrophagesMicroscopy, ConfocalMicroscopy, FluorescenceMycosesNeutrophilsPhagocytosis

Identifiers

PMID25398200
PMCPMC4326660
OpenAlexW2144504759

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.