Trial reportEnvironmental health perspectives2015
Exposure to household air pollution from wood combustion and association with respiratory symptoms and lung function in nonsmoking women: results from the RESPIRE trial, Guatemala.
Trial report in Environmental health perspectives, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.
- Assessing Exposure to Household Air Pollution: A Systematic Review and Pooled Analysis of Carbon Monoxide as a Surrogate Measure of Particulate Matter.Environmental health perspectives · 2017Pooled it
- Biomonitoring Human Exposure to Household Air Pollution and Association with Self-reported Health Symptoms - A Stove Intervention Study in Peru.Environment international · 2016Trial
- Trial
- COPD: the role of neutrophils in inflammation, pathophysiology, and as drug targets.Clinical science (London, England : 1979) · 2025Review
- Article
- Beyond Smoking: Emerging Drivers of COPD and Their Clinical Implications in Low- and Middle-Income Countries: A Narrative Review.Journal of clinical medicine · 2025Review
- Diagnosis of carbon monoxide exposure in clinical research and practice: A scoping review.PloS one · 2025Article
- Concurrent Particulate Matter and Heat Exposure in Working and Non-working Women in Rural Guatemala.Atmosphere · 2024Article
- Estimating personal exposures to household air pollution and plastic garbage burning among adolescent girls in Jalapa, Guatemala.Chemosphere · 2024Article
- Imaging-based assessment of lung function in a population cooking indoors with biomass fuel: a pilot study.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies.International journal of chronic obstructive pulmonary disease · 2023Review
- Impact of solid fuel usage on respiratory symptoms among reproductive aged women: a cross-sectional study in Sri Lanka.BMC public health · 2022Article
- Use of biomass fuels predicts indoor particulate matter and carbon monoxide concentrations; evidence from an informal urban settlement in Fort Portal city, Uganda.BMC public health · 2022Article
- Symptoms and functional limitations related to respiratory health and carbon monoxide poisoning in Tanzania: a cross sectional study.Environmental health : a global access science source · 2022Article
- Household air pollution and COPD: cause and effect or confounding by other aspects of poverty?The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022Review
- Estimating long-term average household air pollution concentrations from repeated short-term measurements in the presence of seasonal trends and crossover.Environmental epidemiology (Philadelphia, Pa.) · 2022Article
- Energy poverty influences urban outdoor air pollution levels during COVID-19 lockdown in south-central Chile.Energy policy · 2021Article
- Spirometry parameter alterations due to exposure to indoor air pollutants in rural homes in Bogotá, Colombia.Environmental science and pollution research international · 2021Article
- The Conundrum of Cleaner Cookstove Interventions: Necessary but Insufficient?American journal of respiratory and critical care medicine · 2021Article
- Survey-based inventory for atmospheric emissions from residential combustion in Vietnam.Environmental science and pollution research international · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundWith 40% of the world's population relying on solid fuel, household air pollution (HAP) represents a major preventable risk factor for COPD (chronic obstructive pulmonary disease). Meta-analyses have confirmed this relationship; however, constituent studies are observational, with virtually none measuring exposure directly.
objectivesWe estimated associations between HAP exposure and respiratory symptoms and lung function in young, nonsmoking women in rural Guatemala, using measured carbon monoxide (CO) concentrations in exhaled breath and personal air to assess exposure.
methodsThe Randomized Exposure Study of Pollution Indoors and Respiratory Effects (RESPIRE) Guatemala study was a trial comparing respiratory outcomes among 504 women using improved chimney stoves versus traditional cookstoves. The present analysis included 456 women with data from postintervention surveys including interviews at 6, 12, and 18 months (respiratory symptoms) and spirometry and CO (ppm) in exhaled breath measurements. Personal CO was measured using passive diffusion tubes at variable times during the study. Associations between CO concentrations and respiratory health were estimated using random intercept regression models.
resultsRespiratory symptoms (cough, phlegm, wheeze, or chest tightness) during the previous 6 months were positively associated with breath CO measured at the same time of symptom reporting and with average personal CO concentrations during the follow-up period. CO in exhaled breath at the same time as spirometry was associated with lower lung function [average reduction in FEV1 (forced expiratory volume in 1 sec) for a 10% increase in CO was 3.33 mL (95% CI: -0.86, -5.81)]. Lung function measures were not significantly associated with average postintervention personal CO concentrations.
conclusionsOur results provide further support for the effects of HAP exposures on airway inflammation. Further longitudinal research modeling continuous exposure to particulate matter against lung function will help us understand more fully the impact of HAP on COPD.
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