Evidence map›Paper›PMID 25397920›Full record

ArticleSensors (Basel, Switzerland)2014

Using bio-functionalized magnetic nanoparticles and dynamic nuclear magnetic resonance to characterize the time-dependent spin-spin relaxation time for sensitive bio-detection.

Shu-Hsien Liao, Kuen-Lin Chen, Chun-Min Wang, Jen-Jie Chieh, Herng-Er Horng, Li-Min Wang, C H Wu, Hong-Chang Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 14 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Shu-Hsien LiaoInstitute of Electro-Optical Science and Technology, National Taiwan Normal University, Taipei 116, Taiwan. shliao@ntnu.edu.tw.
Kuen-Lin ChenDepartment of Electro-Optical Engineering, Kun Shan University, Tainan 710, Taiwan. chwu@phys.nchu.edu.tw.
Chun-Min WangInstitute of Electro-Optical Science and Technology, National Taiwan Normal University, Taipei 116, Taiwan. u20522@hotmail.com.
Jen-Jie ChiehInstitute of Electro-Optical Science and Technology, National Taiwan Normal University, Taipei 116, Taiwan. jjchieh@ntnu.edu.tw.
Herng-Er HorngInstitute of Electro-Optical Science and Technology, National Taiwan Normal University, Taipei 116, Taiwan. phyfv001@ntnu.edu.tw.
Li-Min WangGraduate Institute of Applied Physics and Department of Physics, National Taiwan University, Taipei 106, Taiwan. liminwang@ntu.edu.tw.
C H WuDepartment of Physics, National Chung Hsing University, Taichung 402, Taiwan. chwu@phys.nchu.edu.tw.
Hong-Chang YangDepartment of Electro-Optical Engineering, Kun Shan University, Tainan 710, Taiwan. hcyang@phys.ntu.edu.tw.
National Taiwan Normal University · TWNational Chung Hsing University · TWKun Shan University · TWNational Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, we report the use of bio-functionalized magnetic nanoparticles (BMNs) and dynamic magnetic resonance (DMR) to characterize the time-dependent spin-spin relaxation time for sensitive bio-detection. The biomarkers are the human C-reactive protein (CRP) while the BMNs are the anti-CRP bound onto dextran-coated Fe3O4 particles labeled as Fe3O4-antiCRP. It was found the time-dependent spin-spin relaxation time, T2, of protons decreases as time evolves. Additionally, the ΔT2 of of protons in BMNs increases as the concentration of CRP increases. We attribute these to the formation of the magnetic clusters that deteriorate the field homogeneity of nearby protons. A sensitivity better than 0.1 μg/mL for assaying CRP is achieved, which is much higher than that required by the clinical criteria (0.5 mg/dL). The present MR-detection platform shows promise for further use in detecting tumors, viruses, and proteins.

Indexed as

Biosensing TechniquesCoated Materials, BiocompatibleC-Reactive ProteinDextransEquipment DesignEquipment Failure AnalysisHumansImmunomagnetic SeparationMagnetic Resonance SpectroscopyMagnetite NanoparticlesReproducibility of ResultsSensitivity and SpecificitySpin LabelsCoated Materials, BiocompatibleC-Reactive ProteinDextransMagnetite NanoparticlesSpin Labels

Identifiers

PMID25397920
PMCPMC4279540
OpenAlexW2060548114

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.