ArticlePloS one2014
ARFGAP1 is dynamically associated with lipid droplets in hepatocytes.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Proteomic Analysis Reveals Differential Expression Profiles in Idiopathic Pulmonary Fibrosis Cell Lines.International journal of molecular sciences · 2022Article
- 2-Hydroxypropyl-β-cyclodextrin reduces retinal cholesterol in wild-type and Cyp27a1British journal of pharmacology · 2021Article
- Neutral lipids regulate amphipathic helix affinity for model lipid droplets.The Journal of cell biology · 2020Article
- Article
- Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets.Developmental cell · 2018Article
- Kinesin-dependent mechanism for controlling triglyceride secretion from the liver.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Lipid Droplets: Formation to Breakdown.Lipids · 2017Review
- Regulation and Functions of Autophagic Lipolysis.Trends in endocrinology and metabolism: TEM · 2016Review
- Dropping in on the lipid droplet- tumor protein D52 (TPD52) as a new regulator and resident protein.AdipocyteArticle
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
The ARF GTPase Activating Protein 1 (ARFGAP1) associates mainly with the cytosolic side of Golgi cisternal membranes where it participates in the formation of both COPI and clathrin-coated vesicles. In this study, we show that ARFGAP1 associates transiently with lipid droplets upon addition of oleate in cultured cells. Also, that addition of cyclic AMP shifts ARFGAP1 from lipid droplets to the Golgi apparatus and that overexpression and knockdown of ARFGAP1 affect lipid droplet formation. Examination of human liver tissue reveals that ARFGAP1 is found associated with lipid droplets at steady state in some but not all hepatocytes.
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Registered trials
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