ArticleThe New England journal of medicine2015
Gestational hypertension and preeclampsia in living kidney donors.
Article in The New England journal of medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 3 of them syntheses that pooled it.
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Who cites it
102 citing papers in PubMed, 3 syntheses or guidelines pooled it, 332 citations in OpenAlex.
- Clinical practice guideline on pregnancy and renal disease.BMC nephrology · 2019Guideline
- KDIGO Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors.Transplantation · 2017Guideline
- Kidney-Failure Risk Projection for the Living Kidney-Donor Candidate.The New England journal of medicine · 2016Pooled it
- A Two-Center Randomized Controlled Trial to Assess Financial Incentives for Compliance With Living Kidney Donor Follow-Up in the United States.Clinical transplantation · 2025Trial
- Donor medicine: An emerging field in nephrology.World journal of nephrology · 2026Review
- Recommendations for Living Kidney Donor Follow-Up in Canada.Clinical transplantation · 2026Article
- L-kynurenine or nicotinamide supplementations mitigate uterine decidualization impairments during early pregnancy of uninephrectomized mice.Frontiers in physiology · 2026Article
- Long-Term Risk for Scrotal Hydrocelectomy After Laparoscopic Living Donor Nephrectomy: A Population-Based Matched Cohort Study.Canadian journal of kidney health and disease · 2026Article
- Risk of Inguinal Hernia Repair Following Laparoscopic Living Donor Nephrectomy: A Population-Based Cohort Study.Canadian journal of kidney health and disease · 2026Article
- Assessing the risk of preeclampsia/eclampsia in Mississippi black women with chronic kidney disease using electronic health records.Pregnancy hypertension · 2025Article
- Living Donation and Pregnancy-Related Complications: State of the Evidence and Call To Action for Improved Risk Assessment.Clinical journal of the American Society of Nephrology : CJASN · 2024Review
- Risk of new onset hyperuricemia and chronic kidney disease after living kidney donation through propensity score matching analysis.Scientific reports · 2024Article
- Pregnancy in Glomerular Disease: From Risk Identification to Counseling and Management.Journal of clinical medicine · 2024Review
- Risk Factors for Developing Low Estimated Glomerular Filtration Rate and Albuminuria in Living Kidney Donors.Kidney medicine · 2024Article
- Capillary rarefaction: a missing link in renal and cardiovascular disease?Angiogenesis · 2024Review
- Pregnancy Outcomes in Living Kidney Donors: Protocol of a Population-Based Cohort Study in Three Canadian Provinces.Canadian journal of kidney health and disease · 2024Article
- Long-term Course of Kidney Function in Uterus Transplant Recipients Under Treatment With Tacrolimus and After Transplantectomy: Results of the First Clinical Cohort.Transplantation direct · 2023Article
- Pregnancy in Living Kidney Donors: An Evidence-Based Review.Current transplantation reports · 2023Article
- Article
- Prediction of measured GFR after living kidney donation from pre-donation parameters.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Article
42 more citing papers are in PubMed but not listed here.
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Authors and funding
18 authors at 9 institutions in 2 countries.
Funding
Abstract
backgroundYoung women wishing to become living kidney donors frequently ask whether nephrectomy will affect their future pregnancies.
methodsWe conducted a retrospective cohort study of living kidney donors involving 85 women (131 pregnancies after cohort entry) who were matched in a 1:6 ratio with 510 healthy nondonors from the general population (788 pregnancies after cohort entry). Kidney donations occurred between 1992 and 2009 in Ontario, Canada, with follow-up through linked health care databases until March 2013. Donors and nondonors were matched with respect to age, year of cohort entry, residency (urban or rural), income, number of pregnancies before cohort entry, and the time to the first pregnancy after cohort entry. The primary outcome was a hospital diagnosis of gestational hypertension or preeclampsia. Secondary outcomes were each component of the primary outcome examined separately and other maternal and fetal outcomes.
resultsGestational hypertension or preeclampsia was more common among living kidney donors than among nondonors (occurring in 15 of 131 pregnancies [11%] vs. 38 of 788 pregnancies [5%]; odds ratio for donors, 2.4; 95% confidence interval, 1.2 to 5.0; P=0.01). Each component of the primary outcome was also more common among donors (odds ratio, 2.5 for gestational hypertension and 2.4 for preeclampsia). There were no significant differences between donors and nondonors with respect to rates of preterm birth (8% and 7%, respectively) or low birth weight (6% and 4%, respectively). There were no reports of maternal death, stillbirth, or neonatal death among the donors. Most women had uncomplicated pregnancies after donation.
conclusionsGestational hypertension or preeclampsia was more likely to be diagnosed in kidney donors than in matched nondonors with similar indicators of baseline health. (Funded by the Canadian Institutes of Health Research and others.).
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