Evidence map›Paper›PMID 25396739›Full record

ArticlePloS one2014

Potential conservation of circadian clock proteins in the phylum Nematoda as revealed by bioinformatic searches.

Andrés Romanowski, Matías Javier Garavaglia, María Eugenia Goya, Pablo Daniel Ghiringhelli, Diego Andrés Golombek

Abstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
  3. Role of the clock gene homologFrontiers in neuroscience · 2025
    Article
  4. Article
  5. Contribution of cryptochromes and photolyases for insect life under sunlight.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023
    Article
  6. Article
  7. The Doubletime HomologG3 (Bethesda, Md.) · 2018
    Article
  8. Review
  9. Article
  10. Circadian rhythms identified in Caenorhabditis elegans by in vivo long-term monitoring of a bioluminescent reporter.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrés RomanowskiLaboratorio de Cronobiología, Dto de Ciencia y Tecnología, Universidad Nacional de Quilmes, Bernal, Buenos Aires, Argentina.
Matías Javier GaravagliaLaboratorio de Ingeniería Genética y Biología Celular y Molecular - Área Virosis de Insectos (LIGBCM - AVI), Instituto de Microbiología Básica y Aplicada (IMBA), Dto de Ciencia y Tecnología, Universidad Nacional de Quilmes, Bernal, Buenos Aires, Argentina.
María Eugenia GoyaLaboratorio de Cronobiología, Dto de Ciencia y Tecnología, Universidad Nacional de Quilmes, Bernal, Buenos Aires, Argentina.
Pablo Daniel GhiringhelliLaboratorio de Ingeniería Genética y Biología Celular y Molecular - Área Virosis de Insectos (LIGBCM - AVI), Instituto de Microbiología Básica y Aplicada (IMBA), Dto de Ciencia y Tecnología, Universidad Nacional de Quilmes, Bernal, Buenos Aires, Argentina.
Diego Andrés GolombekLaboratorio de Cronobiología, Dto de Ciencia y Tecnología, Universidad Nacional de Quilmes, Bernal, Buenos Aires, Argentina.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although several circadian rhythms have been described in C. elegans, its molecular clock remains elusive. In this work we employed a novel bioinformatic approach, applying probabilistic methodologies, to search for circadian clock proteins of several of the best studied circadian model organisms of different taxa (Mus musculus, Drosophila melanogaster, Neurospora crassa, Arabidopsis thaliana and Synechoccocus elongatus) in the proteomes of C. elegans and other members of the phylum Nematoda. With this approach we found that the Nematoda contain proteins most related to the core and accessory proteins of the insect and mammalian clocks, which provide new insights into the nematode clock and the evolution of the circadian system.

Indexed as

AnimalsArabidopsisCircadian Rhythm Signaling Peptides and ProteinsComputational BiologyConserved SequenceDrosophila melanogasterMiceModels, StatisticalNematodaNeurospora crassaSpecies SpecificitySynechococcusCircadian Rhythm Signaling Peptides and Proteins

Identifiers

PMID25396739
PMCPMC4232591

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.