Evidence map›Paper›PMID 25396407›Full record

Trial reportThe review of diabetic studies : RDS2014

Effects of pistachio nut supplementation on blood glucose in patients with type 2 diabetes: a randomized crossover trial.

Mahmoud Parham, Saeide Heidari, Ashraf Khorramirad, Mohammad Hozoori, Fatemeh Hosseinzadeh, Lida Bakhtyari, Jamshid Vafaeimanesh

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The review of diabetic studies : RDS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 11 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 11 syntheses or guidelines pooled it, 87 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mahmoud ParhamClinical Research Development Center, Qom University of Medical Sciences, Qom, Iran.
Saeide HeidariFaculty of Nursing and Midwifery, Qom University of Medical Sciences, Qom, Iran.
Ashraf KhorramiradFaculty of Nursing and Midwifery, Qom University of Medical Sciences, Qom, Iran.
Mohammad HozooriNutritional Research Center, Qom University of Medical Sciences, Qom, Iran.
Fatemeh HosseinzadehClinical Research Development Center, Qom University of Medical Sciences, Qom, Iran.
Lida BakhtyariQom University of Medical Sciences, Qom, Iran.
Jamshid VafaeimaneshClinical Research Development Center, Qom University of Medical Sciences, Qom, Iran.
Qom University of Medical Science and Health Services · IRShahid Beheshti University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetes is a chronic, potentially debilitating, and often fatal disease. Dietary strategies to reduce postprandial glycemia are important in the prevention and treatment of diabetes. Nuts are rich in mono- and polyunsaturated fatty acids, which may reduce hyperglycemia and improve metabolism.

objectivesTo evaluate the effectiveness of pistachio nut supplementation on glycemic and inflammatory measures in patients with type 2 diabetes.

methodsIn this double-blind, randomized, placebo-controlled, crossover trial, 48 diabetic patients were equally assigned to groups A and B. Patients in group A received a snack of 25 g pistachio nuts twice a day for 12 weeks and group B received a control meal without nuts. After 12 weeks of intervention, the patients had an 8-week washout. Then the groups were displaced, and group B received the same amount of pistachios for 12 weeks.

resultsWith respect to the total change in variables over both phases, there was a marked decrease in HbA1c (-0.4%) and fasting blood glucose (FBG) concentrations (-16 mg/dl) in the pistachio group compared with the control group (p ≤ 0.001 for both). There was no overall significant change in BMI, blood pressure, HOMA-IR, and C-reactive protein (CRP) concentrations. Analysis of the two phases separately showed a decrease in FBG by 14 mg/dl and in HbA1c by 0.45% in the treatment group (A) after 12 weeks, while no significant differences were seen in group B (control group). In the second phase, FBG decreased from 151.36 ± 39.22 to 137.28 ± 28.65 mg/dl (-14 mg/dl) and HbA1c decreased from 7.42 ± 0.97 to 7.15 ± 0.68 mg/dl (-0.28%, p = 0.013 and p = 0.033, respectively) in the pistachio group (B). Pistachio consumption reduced systolic blood pressure (p = 0.007), BMI (p = 0.011), and CRP (p = 0.002) in patients from the treatment groups, but not insulin resistance.

conclusionsDietary consumption of pistachio nuts as a snack has beneficial effects on glycemic control, blood pressure, obesity, and inflammation markers in diabetic patients.

Indexed as

DietNutsPistaciaAdultBlood GlucoseBlood PressureBody Mass IndexC-Reactive ProteinCross-Over StudiesDiabetes Mellitus, Type 2Double-Blind MethodFemaleGlycated HemoglobinHumansInsulin ResistanceIranBlood GlucoseC-Reactive ProteinGlycated HemoglobinPlacebos

Identifiers

PMID25396407
PMCPMC4310069
OpenAlexW2406376852

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.