Evidence map›Paper›PMID 25396068›Full record

ArticleLupus science & medicine2014

Blood-based candidate biomarkers of the presence of neuropsychiatric systemic lupus erythematosus in children.

Hermine I Brunner, Marisa S Klein-Gitelman, Frank Zelko, Dean W Beebe, Dirk Foell, Jiha Lee, Ahmad Zaal, Jordan Jones, Tresa Roebuck-Spencer, Jun Ying

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lupus science & medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Neuropsychiatric Systemic Lupus Erythematosus in Children: A Scoping Review.Open access rheumatology : research and reviews · 2026
    Review
  3. Review
  4. Article
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  7. Cognitive dysfunction in pediatric systemic lupus erythematosus: current knowledge and future directions.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Hermine I BrunnerDepartment of Pediatrics , University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center , Cincinnati, Ohio , USA ; College of Medicine, University of Cincinnati College of Medicine , Cincinnati, Ohio , USA.
Marisa S Klein-GitelmanDepartment of Psychiatry and Behavioral Science , Northwestern University Feinberg School of Medicine , Chicago, Illinois , USA.
Frank ZelkoDepartment of Psychiatry and Behavioral Science , Northwestern University Feinberg School of Medicine , Chicago, Illinois , USA ; Department of Child and Adolescent Psychiatry , Ann & Robert H Lurie Children's Hospital of Chicago , Chicago, Illinois , USA.
Dean W BeebeDepartment of Pediatrics , University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center , Cincinnati, Ohio , USA ; College of Medicine, University of Cincinnati College of Medicine , Cincinnati, Ohio , USA.
Dirk FoellDepartment of Pediatrics, University of Muenster, Muenster , Germany.
Jiha LeeCollege of Medicine, University of Cincinnati College of Medicine , Cincinnati, Ohio , USA ; Department of Internal Medicine , University of Cincinnati College of Medicine , Cincinnati, Ohio , USA.
Ahmad ZaalDepartment of Pediatrics , University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center , Cincinnati, Ohio , USA.
Jordan JonesDepartment of Pediatrics , University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center , Cincinnati, Ohio , USA ; College of Medicine, University of Cincinnati College of Medicine , Cincinnati, Ohio , USA.
Tresa Roebuck-SpencerCognitive Science Research Center , University of Oklahoma , Norman, Oklahoma , USA.
Jun YingDepartment of Environmental Health , University of Cincinnati College of Medicine , Cincinnati, Ohio , USA.
University of Cincinnati Medical Center · USNorthwestern University · USUniversity of Cincinnati · USCincinnati Children's Hospital Medical Center · USUniversity of Münster · DEUniversity of Oklahoma · US

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR026314 · NCRR · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E. · 2009 to 2011
$14.3M
Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E. · 2012 to 2014
$9.9M
ROLE OF ANGPTL4, AN ANGIOGENIC MEDIATOR, IN ARTHRITISP30AR047363 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI FLICK, MATTHEW J. · 2001 to 2015
$9.2M
NCATS NIH HHS UL1 TR000077NCATS NIH HHS UL1 TR001425NCRR NIH HHS UL1 RR026314NIAMS NIH HHS P30 AR047363
6 · The paper itself

Abstract

objectiveTo examine select brain-reactive proteins for their usefulness to serve as blood-based biomarkers in the screening for neurocognitive deficits in childhood-onset systemic lupus erythematosus (cSLE-NCD).

methodsPatients withcSLE (n=40) were studied longitudinally (month 1; month 18): working memory, psychomotor speed and visuoconstructional ability were assessed using formal neurocognitive testing to determine the presence of cSLE-NCD. Patients also completed the computerised Paediatric Automated Neuropsychological Assessment Metrics. The following brain-reactive proteins were measured in the blood: neutrophil gelatinase associated lipocalin (NGAL), S100B, S100A8/9, antibodies to NR2 glutamate receptor (aNR2-AB), ribosomal-P (aP-AB), glycoprotein-1 (aGP1-AB), and lupus anticoagulant.

resultscSLE-NCD was present in 6 of 40 patients at baseline and 4 of 27 patients with 18-month information. aP-AB positivity was more commonly present with cSLE-NCD than without (p=0.05). aP-ABs were negatively associated with performance on tests assessing working memory, psychomotor speed and visuoconstructional ability in using formal neurocognitive testing. There were also significant negative associations between aP-AB, S100A8/9, aNR2-AB, aGP1-AB, and lupus anticoagulant and accuracy rates on select Paediatric Automated Neuropsychological Assessment Metrics subtests (p<0.05). Over time, decline in cognitive performance was more pronounced among patients with higher NGAL and aNR2-AB levels. Combinations of serum levels of S100A8/9, S100B, NGAL, aNR2-AB and aP-AB were able to identify cSLE-NCD (sensitivity: 100%; specificity 76%) in exploratory analysis.

conclusionsSelect brain-reactive proteins in the blood are associated with cognitive performance and the presence of cSLE-NCD, cross-sectionally and over time. This raises the possibility that testing of these proteins may assist with the screening of cSLE-NCD.

Indexed as

Childhood/paediatric lupusInflammationNPSLEPsychology

Identifiers

PMID25396068
PMCPMC4225735
OpenAlexW1985422371

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.