ArticlePrzeglad gastroenterologiczny2014
Lack of association between human papillomavirus infection and colorectal cancer.
Article in Przeglad gastroenterologiczny, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Association between Human Papillomavirus and Non-cervical Genital Cancers in Brazil: A Systematic Review and Meta-AnalysisAsian Pacific journal of cancer prevention : APJCP · 2018Pooled it
- Human papillomavirus and colorectal cancer.Medical oncology (Northwood, London, England) · 2018Pooled it
- HPV-positive cancers at uncommon sites: a narrative review.Oncology reviews · 2026Review
- Serum level of soluble Interleukin-2 receptor among human papilloma virus infected female patients.Infectious agents and cancer · 2025Article
- Mendelian randomization analyses support causal relationships between HPV infection and colorectal cancer.Discover oncology · 2024Article
- Time to take HPV infection in colorectal cancer patients more seriously.Frontiers in medicine · 2024Article
- Case-control study: Unveiling human polyomaviruses and papillomavirus in Egyptian colorectal cancer patients.PloS one · 2024Article
- Incidence and association of high-risk HPVs and EBV in patients with advanced stages of colorectal cancer from Qatar.Human vaccines & immunotherapeutics · 2023Article
- Coinfection of HPVs Is Associated with Advanced Stage in Colorectal Cancer Patients from Qatar.Pathogens (Basel, Switzerland) · 2023Article
- Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions.Pathogens (Basel, Switzerland) · 2022Review
- Human Papillomavirus Infection and Oropharyngeal and Gastrointestinal Cancers: A Causal Relationship?Diseases (Basel, Switzerland) · 2022Review
- Article
- Human Papillomavirus and Risk of Colorectal Cancer: An Analysis of Nationwide Claims Data.Medicina (Kaunas, Lithuania) · 2022Article
- Viruses in colorectal cancer.Molecular oncology · 2022Review
- Article
- Does human papillomavirus cause human colorectal cancer? Applying Bradford Hill criteria postulates.Ecancermedicalscience · 2020Article
- Human papillomavirus infection & anal cytological abnormalities in HIV-positive men in eastern India.BMC infectious diseases · 2018Article
- Human papillomavirus and gastrointestinal cancer in Iranian population: A systematic review and meta-analysis.Caspian journal of internal medicine · 2017Review
- Absence of high-risk HPV 16 and 18 in Chinese patients with oral squamous cell carcinoma and oral potentially malignant disorders.Virology journal · 2016Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionColorectal cancer is the third leading cause of cancer-related deaths worldwide, with nearly one million new cases identified annually. Different factors might cause colorectal cancer, one of the most prevalent cancers among both men and women. Viral aetiology in cancerous malignancies is a very important issue and so far a number of viral strains have been identified as tumour oncogene viruses. Viral infections, such as human papillomavirus (HPV), have recently been suggested as a risk factor for colorectal cancer. However, the aetiology of the disease is still unknown.
aimTo assessed the association between HPV infection and colorectal cancer. MATERIAL AND
methodsIn this study, 50 cancer tissue samples and 50 samples without colon cancer were studied in order to identify HPV through polymerase chain reaction (PCR). Of 42 adenocarcinomas, 10 were well differentiated, 30 moderated differentiated, and 2 were poorly differentiated. DNA extraction was verified by beta globin gene amplification; specific PCR was carried out based on HPV L1 consensus primers MY09/MY11.
resultsHPV DNA was not identified in any of the normal, adenocarcinoma, or adenoma samples.
conclusionsIn contrast with previous studies, the current research failed to establish a relationship between HPV infection and the incidence of colon cancer. Considering the existing inconsistencies, it is recommended that further studies be conducted with larger sample size.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.