ArticleArchives of medical science : AMS2014
Relationship between single nucleotide polymorphisms in the 3'-untranslated region of the vascular endothelial growth factor gene and susceptibility to diabetic peripheral neuropathy in China.
Article in Archives of medical science : AMS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Genetics of diabetic neuropathy: Systematic review, meta-analysis and trial sequential analysis.Annals of clinical and translational neurology · 2019Pooled it
- Polymorphisms inBiomedicines · 2025Review
- Genetic Variants Influence the Development of Diabetic Neuropathy.International journal of molecular sciences · 2024Review
- Genetic Factors Associated with the Development of Neuropathy in Type 2 Diabetes.International journal of molecular sciences · 2024Article
- Article
- Plasma soluble CD36, carotid intima-media thickness and cognitive function in patients with type 2 diabetes.Archives of medical science : AMS · 2017Article
- Article
- Hyperglycemia and diabetes have different impacts on outcome of ischemic and hemorrhagic stroke.Archives of medical science : AMS · 2017Article
- Impact of diabetes-related gene polymorphisms on the clinical characteristics of type 2 diabetes Chinese Han population.Oncotarget · 2016Article
- Regulation of expression level of fms-like tyrosine kinase-4 is related to osteoclast differentiation.Archives of medical science : AMS · 2016Article
- Novel Genetic Actors of Diabetes-Associated Microvascular Complications: Retinopathy, Kidney Disease and Neuropathy.The review of diabetic studies : RDSArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study is to elucidate the relationship between a 936C/T mutation at the 3'-untranslated region of the human vascular endothelial growth factor (VEGF) gene and diabetic peripheral neuropathy (DPN). MATERIAL AND
methodsAll subjects recruited in this study were divided into DM (diabetes without neuropathy, retinopathy or nephropathy), DPN (diabetes with peripheral neuropathy only) and healthy control groups. The gene polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism, as well as other clinical methods including serum VEGF by ELISA.
resultsThe C allele frequency and CC genotype frequency in the DPN group were higher than those in the NC group and DM group. The T allele frequency and CT+TT genotype (carrying the T allele) frequency in the DPN group were lower than those in the NC group (χ(2) = 19.051 and 18.533, both p < 0.001) and DM group (χ(2) = 11.117 and 11.156, both p = 0.001). However, there was no statistically significant difference in the three genotype (CC/CT+TT) frequencies and allele (C/T) frequencies between the DM group and the NC group. The multivariate logistic regression analysis showed that the levels of glycated hemoglobin (HbA1c), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and plasma VEGF positively correlated with DPN, while the 936C/T gene polymorphism of VEGF negatively correlated with DPN.
conclusionsAllele 936C of VEGF may serve as a genetic marker susceptible to DPN, while allele 936T may be a protective genetic marker of DPN.
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