ArticleNeuropsychiatric disease and treatment2014
Intracranial malignant lesions correlate with the requirement for a long treatment course in postoperative central nervous system infection.
Article in Neuropsychiatric disease and treatment, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 5 citations in OpenAlex.
- Multi-Route Administration Therapy for IntracranialInternational medical case reports journal · 2026Article
- A study of the predictive value of transcranial doppler ultrasound for intracranial infections and the distribution of causative organisms.Scientific reports · 2025Article
- Bacterial Meningitis among Intracranial Surgery Patients at a University Hospital in Northern India.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022Article
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2 authors at 2 institutions in 1 country.
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Abstract
aimOur aim was to study the clinical features of postoperative meningitis after neurosurgery and identify the factors affecting the duration of treatment.
methodsThis retrospective study assessed 283 patients with postoperative bacterial meningitis in the Neurosurgery Department of Beijing Tiantan Hospital, Beijing, People's Republic of China, between January and December 2012. Patients' clinical data were reviewed, and multivariate logistic regression analysis was used to identify the factors associated with a prolonged treatment course.
resultsThe mortality rate was 0.4% in these patients, of whom 12.4% were found with pathogens in the cerebrospinal fluid. Among the three most common pathogens detected were methicillin-resistant Staphylococcus aureus, Acinetobacter baumannii, and Pseudomonas aeruginosa. The mean treatment course was 13.5±2.1 days. Interestingly, the treatment duration for postoperative meningitis was significantly longer in patients with intracranial malignant tumors than in those with benign lesions. Single-factor analysis showed that male sex (P=0.042) and malignant (rather than benign) lesions (P<0.001) were significantly associated with prolonged treatment duration. Multivariate analysis further confirmed that malignant intracranial lesions represented an independent risk factor for prolonged treatment duration (odds ratio: 2.5962; 95% confidence interval: 1.1092-6.6134).
conclusionThe nature of the intracranial lesion is an independent risk factor for the duration of treatment in postoperative meningitis after neurosurgery.
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