ReviewJournal of international oral health : JIOH2014
Oral fluid-based biomarkers in periodontal disease - part 2. Gingival crevicular fluid.
Review in Journal of international oral health : JIOH, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Hemin suppresses interferon responses in periodontal cell models through JAK2-STAT1 inhibition.Frontiers in immunology · 2026Article
- Compositional Changes and Comparative Analysis of Oral Microbial Community During the Formation of Canine Dental Calculus.Animals : an open access journal from MDPI · 2025Article
- Is there a relationship between periodontal conditions and asprosin levels in gingival crevicular fluid, saliva and serum?BMC oral health · 2025Observational
- The Expression Patterns of Non-Coding RNAs in Periodontal Disease.Dentistry journal · 2024Review
- Locally Applied Repositioned Hormones for Oral Bone and Periodontal Tissue Engineering: A Narrative Review.Polymers · 2022Review
- Evaluation of Salivary Biochemistry in Dogs with and without Plaque, Calculus, and Gingivitis: Preliminary Results.Animals : an open access journal from MDPI · 2022Article
- Proteomics Disclose the Potential of Gingival Crevicular Fluid (GCF) as a Source of Biomarkers for Severe Periodontitis.Materials (Basel, Switzerland) · 2022Article
- Update on the Role of Cytokines as Oral Biomarkers in the Diagnosis of Periodontitis.Advances in experimental medicine and biology · 2022Article
- Expression of growth mediators in the gingival crevicular fluid of patients with aggressive periodontitis undergoing periodontal surgery.Clinical oral investigations · 2019Article
- Characterizing the Subgingival Microbiome of Pregnant African American Women.Journal of obstetric, gynecologic, and neonatal nursing : JOGNN · 2019Article
- Odontogenic ameloblast-associated protein (ODAM) in gingival crevicular fluid for site-specific diagnostic value of periodontitis: a pilot study.BMC oral health · 2018Article
- Functional biomarkers for chronic periodontitis and insights into the roles ofNPJ biofilms and microbiomes · 2015Article
- Correlative analysis of plasma and urine neopterin levels in the pre- and post-menopausal women with periodontitis, following nonsurgical periodontal therapy.Journal of Indian Society of PeriodontologyArticle
- Comparative evaluation of serum and gingival crevicular fluid levels of interleukin 21 in periodontally diseased and healthy patients.Journal of circulating biomarkersArticle
- Levels of the interleukins 17A, 22, and 23 and the S100 protein family in the gingival crevicular fluid of psoriatic patients with or without periodontitis.Anais brasileiros de dermatologiaArticle
- Detection of Ostecalcin in gingival Crevicular fluid in a Group of Orthodontic Patients.Journal of International Society of Preventive & Community DentistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontal diagnosis and treatment plan are based on the assessment of probing depth, clinical attachment level, plaque index, gingival index, bleeding on probing, suppuration, furcation involvement, mobility, and radiographic findings. However, these clinical parameters are not sufficiently sensitive and specific to identify disease activity in individual sites or to predict future attachment loss. Hence, attention is focused on the development of diagnostic tools that could screen and differentiate the active inflamed sites and predict future tissue destruction. Gingival crevicular fluid (GCF), has gained great interest on possible diagnostic value in periodontal disease. It contains a large number of proteins and peptides derived from inflamed host tissues. The analysis of the GCF components can reflect the disease status of individual sites and thus, identify potential biomarkers of periodontitis. A literature search was carried out to find out all the available tests that indicate periodontal disease markers in GCF. All major databases were searched to compile the information on published reports between 1999 and 2014. The list of GCF-biomarkers available to date is compiled and presented in a table format. Based on the available literature on GCF biomarkers, it can be concluded that several sensitive and reliable markers are present to detect the presence, severity, and response to treatment. Further studies are warranted to analyze the sensitivity and reliability of these indicators which might help in developing noninvasive tests that could help in the diagnosis of periodontal disease.
Indexed as
Identifiers
25395809PMC4229821W2993382850What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.