ArticleJournal of international oral health : JIOH2014
In vitro Evaluation of Antibacterial Efficacy of Pineapple Extract (Bromelain) on Periodontal Pathogens.
Article in Journal of international oral health : JIOH, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring the Therapeutic Potential of Bromelain: Applications, Benefits, and Mechanisms.Nutrients · 2024Pooled it
- A visual evaluation of oral plaque removal utilizing an adjunct enzyme pre-rinse in orthodontic subjects.The Angle orthodontist · 2020Trial
- Effects of a New Combination of Antibiofilm Enzymes, Antiadhesive Agents, and Liquorice Extracts on Plaque Accumulation in Dogs: An Unicenter, Controlled, and Randomized Study.Journal of veterinary dentistry · 2026Article
- Antimicrobial efficacy of pineapple extract Bromelain againstJournal of conservative dentistry and endodontics · 2025Review
- Bromelain Supplementation in the Management of Otitis Media with Effusion in Children.Children (Basel, Switzerland) · 2024Article
- Evaluation of the physical properties of bromelain-modified biodentine for direct pulp capping.BMC oral health · 2024Article
- The Effect of Ficin Immobilized on Carboxymethyl Chitosan on Biofilms of Oral Pathogens.International journal of molecular sciences · 2023Article
- Article
- Effect of Nebulized BromAc on Rheology of Artificial Sputum: Relevance to Muco-Obstructive Respiratory Diseases.Advances in respiratory medicine · 2023Article
- Bromelain: A Potent Phytomedicine.Cureus · 2022Review
- Article
- Nanozybiotics: Nanozyme-Based Antibacterials against Bacterial Resistance.Antibiotics (Basel, Switzerland) · 2022Review
- Protein extract of Bromelia karatas L. rich in cysteine proteases (ananain- and bromelain-like) has antibacterial activity against foodborne pathogens Listeria monocytogenes and Salmonella Typhimurium.Folia microbiologica · 2022Article
- Bromelain and Nisin: The Natural Antimicrobials with High Potential in Biomedicine.Pharmaceutics · 2021Review
- Beneficial Properties of Bromelain.Nutrients · 2021Review
- Preparation and In Vitro Characterization of Gels Based on Bromelain, Whey and Quince Extract.Gels (Basel, Switzerland) · 2021Article
- Drug Carriers Based on Graphene Oxide and Hydrogel: Opportunities and Challenges in Infection Control Tested by Amoxicillin Release.Materials (Basel, Switzerland) · 2021Article
- Anti-Inflammatory and Mineralization Effects of Bromelain on Lipopolysaccharide-Induced Inflammation of Human Dental Pulp Cells.Medicina (Kaunas, Lithuania) · 2021Article
- Bromelain a Potential Bioactive Compound: A Comprehensive Overview from a Pharmacological Perspective.Life (Basel, Switzerland) · 2021Review
- Applications of bromelain from pineapple waste towards acne.Saudi journal of biological sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeriodontitis is an inflammatory disease resulting in the destruction of periodontal tissues. Various treatment modalities have been tried in the form of mechanical therapy and surgical therapy. Antimicrobial agents have been used as a monotherapy and as an adjunct with mechanical debridement. Various plant extracts have been used as antibacterial agents. Pineapple extract (bromelian) is one such agent. Hence this study was conducted to assess the antibacterial efficacy of bromelain on both aerobic and anaerobic periodontal microorganisms. The aim was to assess the antibacterial efficacy of bromelain on both aerobic and anaerobic periodontal microorganisms. MATERIALS AND
methodsMinimum inhibitory concentration (MIC) of bromelain was tested on isolated strains of Streptococcus mutans, Enterococcus fecalis Aggregatibacter actinomycetemcomitans (Aa), and Porphyromonas gingivalis (Pg) using serial dilution broth method.
resultsS. mutans showed sensitivity at the lowest concentration of 2 mg/ml as compared to E fecalis (31.25 mg/ml) while Pgingivalis showed sensitivity at the lowest concentration of 4.15 mg/ml as compared to Aa (16.6 mg/ml).
conclusionBromelain exerts an antibacterial effect against potent periodontal pathogens; hence, it may be used as an antibacterial agent. However, further trial has to be conducted to validate this result.
Indexed as
Identifiers
25395802PMC4229839What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.