ArticleContemporary clinical dentistry2014
Comparative evaluation of serum C-reactive protein levels in chronic and aggressive periodontitis patients and association with periodontal disease severity.
Article in Contemporary clinical dentistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02666508 (A Randomized Trial of Plaque Identifying Toothpaste on Reduction of Plaque and Inflammation), which is not on this map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Trial of Plaque Identifying Toothpaste on Reduction of Plaque and Inflammation
Who cites it
13 citing papers in PubMed.
- Effect of Supragingival Irrigation with Aerosolized 0.5% Hydrogen Peroxide on Clinical Periodontal Parameters, Markers of Systemic Inflammation, and Morphology of Gingival Tissues in Patients with Periodontitis.Medical science monitor : international medical journal of experimental and clinical research · 2016Trial
- Assessment of periodontal regeneration with blood derivatives: a systematic review and network meta-analysis.Odontology · 2026Review
- Association and predictive value of C-reactive protein, fibrinogen and periodontal indices in periodontitis severity : a cross-sectional study.Clinical oral investigations · 2026Article
- Recent Advancements and Applications of Nanosensors in Oral Health: Revolutionizing Diagnosis and Treatment.European journal of dentistry · 2025Article
- Periodontal disease: A systemic condition.Periodontology 2000 · 2024Review
- Association between periodontitis and COVID-19 severity in a tertiary hospital: A retrospective cohort study.The Saudi dental journal · 2022Article
- Neuroinflammation: A Distal Consequence of Periodontitis.Journal of dental research · 2022Review
- [Effect of inflammaging on periodontitis].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2018Article
- Periodontal disease and its connection to systemic biomarkers of cardiovascular disease in young American Indian/Alaskan natives.Journal of periodontology · 2018Article
- C-reactive protein in patients with aggressive periodontitis.Journal of dental sciences · 2017Article
- Short-term changes on C-reactive protein (CRP) levels after non-surgical periodontal treatment in systemically healthy individuals.Clinical oral investigations · 2017Article
- Cigarette Smoking, Tooth Loss, and Chronic Obstructive Pulmonary Disease: Findings From the Behavioral Risk Factor Surveillance System.Journal of periodontology · 2016Article
- C-Reactive Protein in Peripheral Blood of Patients with Chronic and Aggressive Periodontitis, Gingivitis, and Gingival Recessions.Mediators of inflammation · 2015Article
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Authors and funding
4 authors.
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Abstract
objectiveC-reactive protein (CRP) is an acute-phase reactant and has been proved to be a significant predictor of future cardiovascular events. Recent studies have demonstrated a correlation between periodontitis and elevated CRP levels. However, most of the studies have focused on chronic periodontitis and very few studies are done in patients with aggressive periodontitis. The aim of this study was to determine and compare the relative levels of serum CRP in aggressive and chronic periodontitis patients. MATERIALS AND
methodsA total of 75 systemically healthy subjects were divided into three groups: Group I, nonperiodontitis subjects; group II, chronic generalized periodontitis patients and group III, generalized aggressive periodontitis patients. All participants were subjected to quantitative CRP analysis using enzyme-linked immunosorbent assay.
resultsMean CRP levels were significantly greater in both group II and III as compared to group I and group III having greater level than group II. Furthermore, CRP levels positively correlated with the amount of periodontal destruction as measured by probing depth and clinical attachment loss.
conclusionThe present study indicates a positive correlation between CRP and periodontal disease severity with particular concern in younger individuals that could be a possible underlying pathway in the association between periodontal disease and the observed higher risk for cardiovascular disease in periodontitis patients.
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