Evidence map›Paper›PMID 25395705›Full record

ArticleAfrican journal of traditional, complementary, and alternative medicines : AJTCAM2014

Inhibition of three novel Radix Scutellariae extracts on immediate hypersensitivity.

Xiaorong Li, Jiangning Wang, Haiyun Shi, Lei Gao, Xueyan Wang

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PubMed Full text at PMC Publisher
In one paragraph

Article in African journal of traditional, complementary, and alternative medicines : AJTCAM, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Xiaorong LiCentral Laboratory, The Luhe Teaching Hospital of the Capital Medical University, Beijing, China.
Jiangning WangReparative and reconstructive Sugery, Beijing Shijitan Hospital, Capital Medical University Beijing, China.
Haiyun ShiDepartment of Allergy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Lei GaoPlastic Surgery, The Luhe Teaching Hospital of the Capital Medical University, Beijing, China.
Xueyan WangDepartment of Allergy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Beijing Luhe Hospital Affiliated to Capital Medical University · CNBeijing Shijitan Hospital · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRadix Scutellariae, a few papers reported its pharmacology activities including alleviate small intestines smooth muscles spasm, sedation, antihypertensive effect. However, the inhibition of its different organic extracts on immediate hypersensitivity has not bee researched. MATERIALS AND

methodsTo investigate the anti-immediate hypersensitivity of three extracts including ethanol extracts, acetone extracts, ethyl acetate extracts from Radix Scutellariae, four pharmacological screening model were chose, such as 4-Aminopyridine induced pruritus model, histamine-induced mouse paw edema model, PCA(passive cutaneous anaphylaxis) in ear of mouse, activie cutaneous anaphylaxismouse (mouse ear edema test), furthermore, total IgE level in the sensitized mice serum was evaluated deeply.

resultsEthanol group at 1.42 g/kg and 0.71 g/kg could greatly decrease the licking number to 1.2 and 12.7 respectively; also keep mice paw swelling at 0.29 ml and 0.51 ml at 15 min after injection of histamine. Both ear passive cutaneous allergic reaction and active cutaneous anaphylaxis-ear swelling test demonstrated that ethanol group exhibit great inhibition on immediate hypersensitivity.Low IgE level was found in ethanol group, but high in other two groups.

conclusionThe ethanol extracts exhibits obvious strong inhibition, however, the acetone ones and ethyl acetate showed a little.

Indexed as

PhytotherapyScutellaria baicalensisAminopyridinesAnaphylaxisAnimalsAnti-Allergic AgentsBehavior, AnimalDrugs, Chinese HerbalEarEdemaFemaleHypersensitivity, ImmediateImmunoglobulin EMaleMicePassive Cutaneous AnaphylaxisAminopyridinesAnti-Allergic AgentsDrugs, Chinese HerbalImmunoglobulin EAnti-allergic activityEthanol extractsIgE levelPCARadix Scutellariae

Identifiers

PMID25395705
PMCPMC4202518
OpenAlexW2004758305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.