Evidence map›Paper›PMID 25395683›Full record

ArticleBiostatistics (Oxford, England)2015

Sensitivity analyses for parametric causal mediation effect estimation.

Jeffrey M Albert, Wei Wang

Open access · bronzeAbstract read
In one paragraph

Article in Biostatistics (Oxford, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 37 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Causal mediation and sensitivity analysis for mixed-scale data.Statistical methods in medical research · 2023
    Article
  5. A Review of High-Dimensional Mediation Analyses in DNA Methylation Studies.Methods in molecular biology (Clifton, N.J.) · 2022
    Review
  6. Acute exercise effects on inhibitory control and the pupillary response in young adults.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2021
    Article
  7. Relationships between enriching early life experiences and cognitive function later in life are mediated by educational attainment.Journal of cognitive enhancement : towards the integration of theory and practice · 2021
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Continuous-time causal mediation analysis.Statistics in medicine · 2019
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Causal Mediation Analysis for the Cox Proportional Hazards Model with a Smooth Baseline Hazard Estimator.Journal of the Royal Statistical Society. Series C, Applied statistics · 2017
    Article
  18. Article
  19. Causal mediation analysis with a latent mediator.Biometrical journal. Biometrische Zeitschrift · 2016
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Jeffrey M AlbertDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA jma13@case.edu.
Wei WangCenter for Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Case Western Reserve University · USUniversity of Mississippi Medical Center · US

Funding

Generalized Causal Mediation Analysis for Social Environment and Health ResearchR01DE022674 · NIDCR · CASE WESTERN RESERVE UNIVERSITY · PI ALBERT, JEFFREY M · 2011 to 2015
$1.1M
Oral Health Problems of BPD and VLBW adolescentsR21DE016469 · NIDCR · CASE WESTERN RESERVE UNIVERSITY · PI NELSON, SUCHITRA S · 2004 to 2005
$421k
NIDCR NIH HHS R01 DE022674NIDCR NIH HHS R01DE022674NIDCR NIH HHS R21 DE016469NIDCR NIH HHS R21-DE16469
6 · The paper itself

Abstract

Causal mediation analysis uses a potential outcomes framework to estimate the direct effect of an exposure on an outcome and its indirect effect through an intermediate variable (or mediator). Causal interpretations of these effects typically rely on sequential ignorability. Because this assumption is not empirically testable, it is important to conduct sensitivity analyses. Sensitivity analyses so far offered for this situation have either focused on the case where the outcome follows a linear model or involve nonparametric or semiparametric models. We propose alternative approaches that are suitable for responses following generalized linear models. The first approach uses a Gaussian copula model involving latent versions of the mediator and the final outcome. The second approach uses a so-called hybrid causal-observational model that extends the association model for the final outcome, providing a novel sensitivity parameter. These models, while still assuming a randomized exposure, allow for unobserved (as well as observed) mediator-outcome confounders that are not affected by exposure. The methods are applied to data from a study of the effect of mother education on dental caries in adolescence.

Indexed as

Models, StatisticalSensitivity and SpecificityAdolescentDental CariesEducational StatusHumansOutcome Assessment, Health CareCausal inferenceCopulaInteractionMediation analysisMediation formulaPotential outcomeStructural equations model

Identifiers

PMID25395683
PMCPMC4441101
OpenAlexW2323757243

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.